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Optical imaging of oral squamous cell carcinoma using optical coherence tomography and micro CT

Canjau, S. and Todea, C. and Sinescu, C. and Negrutiu, M.L. and Duma, V.F. and Manescu, A. and Topala, F.I. and Podoleanu, Adrian G.H. (2014) Optical imaging of oral squamous cell carcinoma using optical coherence tomography and micro CT. Trans Tech Publications Ltd, Bucharest. (doi:10.4028/www.scientific.net/KEM.587.331) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://www.dx.doi.org/10.4028/www.scientific.net/K...

Abstract

Oral squamous cell carcinoma (OSCC) constitutes 90% of oral cancer. Early detection is a cornerstone to improve survival and to reduce diagnostic delay. We propose optical coherence tomography (OCT), as a non-invasive diagnosis method. OCT represents a new high-resolution optical technique that permits 3D, real-time imaging of near surface abnormalities in complex tissues. In the present study half of the excisional biopsy was directed to the pathologist and the other half was assigned for OCT and Micro-CT investigation. For the OCT imaging it was used an OCT prototype (1300 nm), Synchrotron Radiation Micro-CT and histopathology validated the results. Areas of OSCC of the buccal mucosa were identified in the OCT images by the disruption of the basement membrane, an epithelial layer that was highly variable in thickness, with areas of erosion, extensive epithelial down-growth and invasion into the sub-epithelial layers. In this respect, OCT seems to be a highly promising imaging modality. © (2014) Trans Tech Publications, Switzerland.

Item Type: Other
DOI/Identification number: 10.4028/www.scientific.net/KEM.587.331
Additional information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Key Eng Mat [Field not mapped to EPrints] AD - Department of Oral Rehabilitation and Dental Emergencies, University of Medicine and Pharmacy, Pta Eftimie Murgu No. 2, Timisoara, Romania [Field not mapped to EPrints] AD - Department of Dental Materials, University of Medicine and Pharmacy, Pta Eftimie Murgu No. 2, Timisoara, Romania [Field not mapped to EPrints] AD - Department of Product Design, Faculty of Engineering, Aurel Vlaicu University Arad, B-dul Revoluţiei No. 77, Arad, Romania [Field not mapped to EPrints] AD - Department DISCO, Universita Politecnica Delle Marche, Piazza Roma No.22, Ancona, Italy [Field not mapped to EPrints] AD - Department of Prosthodontics, University of Medicine and Pharmacy, Pta Eftimie Murgu No. 2, Timisoara, Romania [Field not mapped to EPrints] AD - Applied Optics Group, University of Kent, Canterbury, Kent CT2 7NZ, United Kingdom [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints] C3 - Key Engineering Materials [Field not mapped to EPrints]
Uncontrolled keywords: Micro-CT, Non-invasive diagnosis, Optical coherence tomography, Oral squamous cell carcinoma, Bioceramics, Optical tomography, Basement membrane, Epithelial down-growth, Imaging modality, Micro CT, Non-invasive diagnosis, Optical technique, Oral squamous cell carcinomata, Realtime imaging, Computerized tomography
Subjects: Q Science > QC Physics
R Medicine > R Medicine (General) > R857.O6 Optical coherence tomography
Divisions: Faculties > Sciences > School of Physical Sciences > Applied Optics Group
Depositing User: Giles Tarver
Date Deposited: 15 Jul 2015 08:33 UTC
Last Modified: 29 May 2019 14:47 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/49303 (The current URI for this page, for reference purposes)
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