Closed loop tracked Doppler optical coherence tomography based heart monitor for the Drosophila melanogaster larvae

Zurauskas, M. and Bradu, Adrian and Ferguson, D.R. and Hammer, D.X. and Podoleanu, Adrian G.H. (2015) Closed loop tracked Doppler optical coherence tomography based heart monitor for the Drosophila melanogaster larvae. Journal of Biophotonics, . ISSN 1864-063X. E-ISSN 1864-0648. (doi:https://doi.org/10.1002/jbio.201500007) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org/10.1002/jbio.201500007

Abstract

This paper presents a novel instrument for biosciences, useful for studies of moving embryos. A dual sequential imaging/measurement channel is assembled via a closed-loop tracking architecture. The dual channel system can operate in two regimes: (i) single-point Doppler signal monitoring or (ii) fast 3-D swept source OCT imaging. The system is demonstrated for characterizing cardiac dynamics in Drosophila melanogaster larva. Closed loop tracking enables long term in vivo monitoring of the larvae heart without anesthetic or physical restraint. Such an instrument can be used to measure subtle variations in the cardiac behavior otherwise obscured by the larvae movements. A fruit fly larva (top) was continuously tracked for continuous remote monitoring. A heartbeat trace of freely moving larva (bottom) was obtained by a low coherence interferometry based doppler sensing technique.

Item Type: Article
Uncontrolled keywords: Doppler sensing, Drosophila melanogaster, Optical coherence tomography, Optical tracking,
Subjects: Q Science > QC Physics
Q Science > QC Physics > QC355 Optics
R Medicine > R Medicine (General) > R857.O6 Optical coherence tomography
Divisions: Faculties > Sciences > School of Physical Sciences > Applied Optics Group
Depositing User: Giles Tarver
Date Deposited: 10 Jul 2015 10:06 UTC
Last Modified: 19 Feb 2016 13:52 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/49269 (The current URI for this page, for reference purposes)
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