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Tetrahydrofuran-Based Amino Acids as Library Scaffolds

Edwards, Alison A., Ichihara, Osamu, Murfin, Stephen, Wilkes, Robin, Whittaker, Mark, Watkin, David J., Fleet, George W.J. (2004) Tetrahydrofuran-Based Amino Acids as Library Scaffolds. Journal of Combinatorial Chemistry, 6 (2). pp. 230-238. ISSN 1520-4766. (doi:10.1021/cc034054r) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Abstract

A furanose sugar amino acid (SAA) has been utilized as a library scaffold for the first time. Two furanose

contained three orthogonal points of diversification that allowed easy access to ethers and carbamates from

ester. The novel amide formation (by displacement of the methoxide from the methyl ester moiety) was

intermediates (including a crystal structure) was obtained. The library was submitted for antibacterial screening.

Item Type: Article
DOI/Identification number: 10.1021/cc034054r
Subjects: Q Science
Q Science > QD Chemistry
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Alison Edwards
Date Deposited: 28 May 2009 14:31 UTC
Last Modified: 12 Feb 2020 04:00 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/4885 (The current URI for this page, for reference purposes)
Edwards, Alison A.: https://orcid.org/0000-0002-4637-9373
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