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Advanced systems and methods for collecting accurate data in optical coherence tomography

Žurauskas, Mantas (2014) Advanced systems and methods for collecting accurate data in optical coherence tomography. Doctor of Philosophy (PhD) thesis, University of Kent,. (KAR id:48728)

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Abstract

Optical coherence tomography (OCT) has recently emerged as a valuable technique in biomedical research and medical diagnostics. OCT based instruments allow acquisi- tion of high-resolution information about the internal structure of translucent organs and tissues without damaging the object. However, unaccounted object movements reduce the quality of acquired data, particularly in functional imaging and in OCT modalities that rely on continuous monitoring. Therefore there is a need for methods that allow mitigating the negative effects of the object movements on the data quality.

Furthermore, we have demonstrated how the multiplexer can be applied to extend the sensitivity range in swept source based OCT systems. The experiments presented in this thesis illustrate the flexibility of our new multiplexing method, which has proven useful not only for increasing the accuracy of collected data, but as well for increasing the efficiency in using the light from the object.

Alternatively, we have investigated tracking as a way to improve the quality of the OCT data acquired from the moving targets. We have demonstrated a closed-loop tracking based set-up that uses low coherence interferometry to continuously monitor the cardiac dynamics of a Drosophila melanogaster embryo.

Item Type: Thesis (Doctor of Philosophy (PhD))
Thesis advisor: Podoleanu, Adrian G.H.
Uncontrolled keywords: Optical coherence tomography, Tracking, PS-OCT, Drosophila
Subjects: Q Science > QC Physics > QC355 Optics
Divisions: Faculties > Sciences > School of Physical Sciences > Applied Optics Group
Depositing User: Users 1 not found.
Date Deposited: 04 Jun 2015 11:00 UTC
Last Modified: 26 Jan 2020 04:07 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/48728 (The current URI for this page, for reference purposes)
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