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Central alterations of neuromuscular function and feedback from group III-IV muscle afferents following exhaustive high intensity one leg dynamic exercise

Pageaux, Benjamin, Angius, Luca, Hopker, James G., Lepers, Romuald, Marcora, Samuele Maria (2015) Central alterations of neuromuscular function and feedback from group III-IV muscle afferents following exhaustive high intensity one leg dynamic exercise. American journal of physiology - Regulatory, integrative and comparative physiology, 308 (12). R1008-R1020. ISSN 0363-6119. E-ISSN 1522-1490. (doi:10.1152/ajpregu.00280.2014) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org/10.1152/ajpregu.00280.2014

Abstract

The aims of this investigation were to describe the central alterations of neuromuscular function induced by exhaustive high intensity one leg dynamic exercise (OLDE, study 1), and to indirectly quantify feedback from group III-IV muscle afferents via muscle occlusion (MO, study 2) in healthy adult male humans. We hypothesized that these central alterations and their recovery are associated with changes in afferent feedback. Both studies consisted of two time to exhaustion tests at 85% peak power output. In study 1, voluntary activation level (VAL), M-wave (M), cervicomedullary motor evoked potential (CMEP), motor evoked potential (MEP) and MEP cortical silent period (CSP) of the knee extensor muscles were measured. In study 2, mean arterial pressure (MAP) and leg muscle pain were measured during MO. Measurements were performed pre-exercise, at exhaustion and after three minutes recovery. Compared to pre-exercise values, VAL was lower at exhaustion (-13±13%, P<0.05) and after three minutes recovery (-6±6%, P=0.05). CMEParea/Marea was lower at exhaustion (-38±13%, P<0.01) and recovered after three minutes. MEParea/Marea was higher at exhaustion (+25±27%, P<0.01) and after three minutes recovery (+17±20%, P<0.01). CSP was higher (+19±9%, P<0.01) only at exhaustion and recovered after three minutes. Markers of afferent feedback (MAP and leg muscle pain during MO) were significantly higher only at exhaustion. These findings suggest that the alterations in spinal excitability and CSP induced by high intensity OLDE are associated with an increase in afferent feedback at exhaustion, whilst central fatigue does not fully recover even when significant afferent feedback is no longer present.

Item Type: Article
DOI/Identification number: 10.1152/ajpregu.00280.2014
Uncontrolled keywords: central fatigue; muscle fatigue; corticospinal excitability; cervicomedullary stimulation; endurance performance
Subjects: R Medicine > RC Internal medicine > RC1235 Physiology of sports
Divisions: Faculties > Sciences > School of Sport and Exercise Sciences
Depositing User: James Hopker
Date Deposited: 19 May 2015 18:57 UTC
Last Modified: 29 May 2019 14:35 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/48578 (The current URI for this page, for reference purposes)
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