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Retroviral Pseudotypes – From Scientific Tools to Clinical Utility

Temperton, Nigel J. and Wright, Edward and Scott, Simon D. (2015) Retroviral Pseudotypes – From Scientific Tools to Clinical Utility. In: Encyclopaedia of Life Sciences. Wiley. E-ISBN 978-0-470-01590-2. (doi:10.1002/9780470015902.a0021549.pub2) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
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http://dx.doi.org/10.1002/9780470015902.a0021549.p...

Abstract

Retroviral pseudotypes are important research and diagnostic tools for basic and clinical virology studies, facilitating the detailed investigation of individual genes, cellular receptors, antibody responses, sero-surveillance and antiviral therapies. Importantly, pseudotypes enable the study of highly pathogenic viruses, without the need for high containment. Their use as gene therapy vectors is widely documented, but other uses, once less well known, are becoming more prominent. The substitution of envelope proteins expressed on the virion surface enables pseudotypes to be employed as surrogates for wildtype viruses in antibody neutralization or antiviral screening assays and for the study of cell–virus receptor interactions. In addition, they are increasingly being utilised as vaccine immunogens, expressing the antigen either on the particle surface or as a transfer gene for cellular expression. These studies demonstrate the potential for using pseudotypes for both scientific and clinical applications.

Item Type: Book section
DOI/Identification number: 10.1002/9780470015902.a0021549.pub2
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Nigel Temperton
Date Deposited: 05 Mar 2015 08:31 UTC
Last Modified: 29 May 2019 14:18 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/47546 (The current URI for this page, for reference purposes)
Temperton, Nigel J.: https://orcid.org/0000-0002-7978-3815
Scott, Simon D.: https://orcid.org/0000-0002-8290-0461
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