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An atomic scale comparison of the reaction of Bioglass® in two types of simulated body fluid

Newport, Robert J., FitzGerald, V., Pickup, D.M., Greenspan, D., Wetherall, K.M., Moss, R.M., Jones, J.R. (2009) An atomic scale comparison of the reaction of Bioglass® in two types of simulated body fluid. Physics and Chemistry of Glasses: European Journal of Glass Science and Technology Part B, 50 (3). pp. 137-143. ISSN 0031-9090. (KAR id:47140)


A class of melt quenched silicate glasses, containing calcium, phosphorus and alkali metals, and having the ability to promote bone regeneration and to fuse to living bone, is produced commercially as Bioglass. The changes in structure associated with reacting the bioglass with a body fluid simulant (a buffered Tris(hydroxymethyl)aminomethane growth medium solution or a blood plasma-like salt simulated body fluid) at 37°C have been studied using both high energy and grazing incidence x-ray diffraction. This has corroborated the generic conclusions of earlier studies based on the use of calcia–silica sol-gel glasses whilst highlighting the important differences associated with glass composition; the results also reveal the more subtle effects on reaction rates of the choice of body fluid simulant. The results also indicate the presence of tricalcium phosphate crystallites deposited onto the surface of the glass as a precursor to the growth of hydroxyapatite, and indicates that there is some preferred orientation to their growth.

Item Type: Article
Additional information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Phys. Chem. Glasses Euro. J. Glass Sci. Technol. Part B [Field not mapped to EPrints] AD - School of Physical Sciences, University of Kent, Canterbury, CT2 7NH, United Kingdom [Field not mapped to EPrints] AD - Novamin Technology Inc., 13859 Progress Blvd., Alachua, FL 32615, United States [Field not mapped to EPrints] AD - Department of Materials, Imperial College London, London, SW7 2AZ, United Kingdom [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled keywords: Atomic scale, Bio-glass, Blood plasma, Bone regeneration, Glass compositions, Grazing incidence X-ray diffraction, Growth medium, High energy, Living bone, Preferred orientations, Silica sol gels, Silicate glass, Simulated body fluids, Tri-calcium phosphates, Trishydroxymethylaminomethane, Alkali metals, Biomaterials, Blood, Bone, Calcium, Calcium silicate, Gels, Glass, Hydroxyapatite, Methanol, Phosphorus, Reaction rates, Silica, Silicates, Smelting, X ray diffraction, Fluids
Subjects: Q Science > QC Physics > QC173.45 Condensed Matter
Q Science > QD Chemistry > QD478 Solid State Chemistry
Divisions: Divisions > Division of Natural Sciences > Physics and Astronomy
Depositing User: Giles Tarver
Date Deposited: 16 Feb 2015 16:20 UTC
Last Modified: 16 Nov 2021 10:19 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Newport, Robert J..

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FitzGerald, V..

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Pickup, D.M..

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