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Candida Biofilm Formation on Voice Prostheses

Talpaert, Moira J, Balfour, Alistair, Stevens, Sarah, Baker, Mark, Mühlschlegel, Fritz A., Gourlay, Campbell W. (2015) Candida Biofilm Formation on Voice Prostheses. Journal of medical microbiology, 64 (Pt 3). pp. 199-208. ISSN 0022-2615. (doi:10.1099/jmm.0.078717-0) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:47016)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1099/jmm.0.078717-0

Abstract

Laryngopharyngeal malignancy is treated with radiotherapy and/or surgery. When total laryngectomy is required major laryngeal functions (phonation, airway control, swallowing, and coughing) are affected. The insertion of a silicone rubber voice prosthesis in a surgically created tracheoesophageal puncture is the most effective method for voice rehabilitation. Silicone has the propensity to become rapidly colonised by microorganisms (mainly Candida albicans) forming a biofilm which leads to the failure of the devices. Valve failure, as well as compromising speech, may result in aspiration pneumonia, and repeated valve replacement may lead to either tract stenosis or insufficiency. Prevention and control of biofilm formation is therefore crucial for the lifespan of the prosthesis and promotion of tracheosophageal tissue and lung health. To date the mechanisms of biofilm formation on voice prostheses are not fully understood. Further studies are therefore required to identify factors influencing Candida biofilm formation. This review describes the factors known to influence biofilm formation on voice prosthesis and current strategies employed to prolong their life by interfering with microbial colonisation.

Item Type: Article
DOI/Identification number: 10.1099/jmm.0.078717-0
Subjects: Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Depositing User: Campbell Gourlay
Date Deposited: 30 Jan 2015 11:37 UTC
Last Modified: 06 Feb 2020 04:11 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/47016 (The current URI for this page, for reference purposes)
Gourlay, Campbell W.: https://orcid.org/0000-0002-2373-6788
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