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Bioactive glass scaffolds for bone regeneration and their hierarchical characterisation

Jones, J.R., Lin, S., Yue, S., Lee, P.D., Hanna, J.V., Smith, M.E., Newport, Robert J. (2010) Bioactive glass scaffolds for bone regeneration and their hierarchical characterisation. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 224 (12). pp. 1373-1387. ISSN 0954-4119. (doi:10.1243/09544119JEIM836) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1243/09544119JEIM836

Abstract

Scaffolds are needed that can act as temporary templates for bone regeneration and actively stimulate vascularized bone growth so that bone grafting is no longer necessary. To achieve this, the scaffold must have a suitable interconnected pore network and be made of an osteogenic material. Bioactive glass is an ideal material because it rapidly bonds to bone and degrades over time, releasing soluble silica and calcium ions that are thought to stimulate osteoprogenitor cells. Melt-derived bioactive glasses, such as the original Bioglass® composition, are available commercially, but porous scaffolds have been difficult to produce because Bioglass and similar compositions crystallize on sintering. Sol-gel foam scaffolds have been developed that avoid this problem. They have a hierarchical pore structure comprising interconnected macropores, with interconnect diameters in excess of the 100 μm that is thought to be needed for vascularized bone ingrowth, and an inherent nanoporosity of interconnected mesopores (2-50 nm) which is beneficial for the attachment of osteoprogenitor cells. They also have a compressive strength in the range of cancellous bone. This paper describes the optimized sol-gel foaming process and illustrates the importance of optimizing the hierarchical structure from the atomic through nano, to the macro scale with respect to biological response.

Item Type: Article
DOI/Identification number: 10.1243/09544119JEIM836
Additional information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Proc. Inst. Mech. Eng. Part H J. Eng. Med. [Field not mapped to EPrints] C2 - 21287826 [Field not mapped to EPrints] AD - Department of Materials, Imperial College London, South Kensington Campus, Prince Consort Road, London SWT 2AZ, United Kingdom [Field not mapped to EPrints] AD - Department of Physics, University of Warwick, Coventry, United Kingdom [Field not mapped to EPrints] AD - School of Physical Sciences, Ingram Building, University of Kent, Canterbury, United Kingdom [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled keywords: bioactive glass, bone regeneration, image analysis, nanostructure, NMR, scaffolds, tissue engineering, X-ray microtomography, XRD, Biological response, Bone grafting, Bone growth, Bone ingrowth, Bone regeneration, Calcium ions, Cancellous bone, Foam scaffolds, Foaming process, Hierarchical structures, Interconnected pore networks, Macro scale, Macropores, Meso-pores, Nanoporosity, Osteogenic materials, Osteoprogenitor cells, Porous scaffold, X ray microtomography, XRD, Bioactive glass, Bone, Image analysis, Nanostructures, Nuclear magnetic resonance, Optimization, Scaffolds, Silica, Sintering, Sol-gel process, Sol-gels, Tissue engineering, Scaffolds (biology), tissue scaffold, animal, bone development, bone prosthesis, bone regeneration, chemistry, human, instrumentation, materials, methodology, physiology, review, tissue engineering, Animals, Bone Development, Bone Regeneration, Bone Substitutes, Humans, Manufactured Materials, Tissue Engineering, Tissue Scaffolds
Subjects: Q Science > QC Physics > QC173.45 Condensed Matter
Q Science > QD Chemistry > QD478 Solid State Chemistry
Divisions: Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Giles Tarver
Date Deposited: 11 Feb 2015 13:42 UTC
Last Modified: 29 May 2019 14:09 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/46965 (The current URI for this page, for reference purposes)
Newport, Robert J.: https://orcid.org/0000-0002-2365-992X
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