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Sol-gel phosphate-based glass for drug delivery applications

Pickup, D.M., Newport, Robert J., Knowles, J.C. (2012) Sol-gel phosphate-based glass for drug delivery applications. Journal of Biomaterials Applications, 26 (5). pp. 613-622. ISSN 0885-3282. (doi:10.1177/0885328210380761) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1177/0885328210380761

Abstract

Development of controlled, targeted drug delivery systems represents one of the frontier areas of biomaterials science, where a multidisciplinary approach is of direct benefit to human healthcare. We demonstrate herein the potential of sol-gel derived phosphate-based glass for use in drug delivery applications. Our low-temperature sol-gel synthesis of phosphate-based glasses has made it possible to incorporate relatively unstable functional molecules for controlled release. We demonstrate the potential of this approach by incorporating the chemotherapy agent cisplatin in a CaO-Na2O-P2O5 glass. X-ray absorption spectroscopy is used to show that the chlorine ligands of cisplatin undergo exchange with oxygen during the synthesis, consistent with binding to the phosphate groups of the sol-gel. UV-visible spectroscopy reveals the subsequent release of cisplatin into an aqueous medium.

Item Type: Article
DOI/Identification number: 10.1177/0885328210380761
Additional information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Biomater. Appl. [Field not mapped to EPrints] C2 - 20819917 [Field not mapped to EPrints] AD - School of Physical Sciences, Ingram Building, University of Kent Canterbury, Kent, CT2 7NH, United Kingdom [Field not mapped to EPrints] AD - Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, London, WC1X 8LD, United Kingdom [Field not mapped to EPrints] AD - WCU Research Centre of Nanobiomedical Science, Dankook University, San#29, Anseo-dong, Dongnam-gu, Cheonan-si, Chungnam 330-714, South Korea [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled keywords: cisplatin, drug delivery, EXAFS, phosphate glass, sol-gel, Aqueous medium, Chemotherapy agents, Cis-platin, Controlled release, Drug delivery applications, EXAFS, Functional molecules, Low temperatures, Multi-disciplinary approach, phosphate glass, Phosphate group, Sol-gel synthesis, Targeted drug delivery, UV visible spectroscopy, Biological materials, Chelation, Chemotherapy, Chlorine, Drug delivery, Gels, Glass, Health care, Platinum compounds, Sol-gel process, Sol-gels, Sols, Synthesis (chemical), Ultraviolet visible spectroscopy, X ray absorption spectroscopy, Controlled drug delivery, antineoplastic agent, cisplatin, glass, phosphate, article, chemistry, delayed release formulation, phase transition, X ray absorption spectroscopy, Antineoplastic Agents, Cisplatin, Delayed-Action Preparations, Glass, Phase Transition, Phosphates, X-Ray Absorption Spectroscopy
Subjects: Q Science > QC Physics > QC173.45 Condensed Matter
Q Science > QD Chemistry > QD478 Solid State Chemistry
Divisions: Faculties > Sciences > School of Physical Sciences
Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Giles Tarver
Date Deposited: 12 Feb 2015 14:54 UTC
Last Modified: 29 May 2019 14:09 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/46960 (The current URI for this page, for reference purposes)
Newport, Robert J.: https://orcid.org/0000-0002-2365-992X
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