Smith, J.M., Martin, R.A., Cuello, G.J., Newport, Robert J. (2013) Structural characterisation of hypoxia-mimicking bioactive glasses. Journal of Materials Chemistry B, 1 (9). pp. 1296-1303. ISSN 2050-7518. (doi:10.1039/c3tb00408b) (KAR id:46951)
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Official URL: http://dx.doi.org/10.1039/C3TB00408B |
Abstract
Nickel and cobalt are both known to stimulate the hypoxia-inducible factor-1 (HIF-1α), thus significantly improving blood vessel formation in tissue engineering applications. We have manufactured nickel and cobalt doped bioactive glasses to act as a controlled delivery mechanism of these ions. The resultant structural consequences have been investigated using the methods of isotopic and isomorphic substitution applied to neutron diffraction. The structural sites present will be intimately related to their release properties in physiological fluids such as plasma and saliva, and hence the bioactivity of the material. Detailed structural knowledge is therefore a prerequisite for optimising material design. Results show that nickel and cobalt adopt a mixed structural role within these bioactive glasses occupying both network-forming (tetrahedral) and network-modifying (5-fold) geometries. Two thirds of the Ni (or Co) occupies a five-fold geometry with the remaining third in a tetrahedral environment. A direct comparison of the primary structural correlations (e.g. Si–O, Ca–O, Na–O and O–Si–O) between the archetypal 45S5 Bioglass® and the Ni and Co glasses studied here reveal no significant differences. This indicates that the addition of Ni (or Co) will have no adverse effects on the existing structure, and thus on in vitro/in vivo dissolution rates and therefore bioactivity of these glasses.
Item Type: | Article |
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DOI/Identification number: | 10.1039/c3tb00408b |
Additional information: | Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Mater. Chem. B [Field not mapped to EPrints] AD - School of Physical Sciences, University of Kent, Ingram Building, Canterbury, CT2 7NH, United Kingdom [Field not mapped to EPrints] AD - School of Engineering and Applied Science, Aston Research Centre for Healthy Ageing, University of Aston, Aston Triangle, Birmingham, B4 7ET, United Kingdom [Field not mapped to EPrints] AD - Institut Laue-Langevin, BP 156, F-38042, Grenoble Cédex 9, France [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints] |
Uncontrolled keywords: | Controlled delivery, Hypoxia-inducible factor 1, Isomorphic substitution, Physiological fluids, Significant differences, Structural correlation, Structural knowledge, Tissue engineering applications, Blood vessels, Cobalt, Neutron diffraction, Nickel, Silicon, Tissue engineering, Bioactive glass |
Subjects: |
Q Science > QC Physics > QC173.45 Condensed Matter Q Science > QD Chemistry > QD478 Solid State Chemistry |
Divisions: | Divisions > Division of Natural Sciences > Physics and Astronomy |
Depositing User: | Giles Tarver |
Date Deposited: | 11 Feb 2015 13:53 UTC |
Last Modified: | 10 Dec 2022 04:08 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/46951 (The current URI for this page, for reference purposes) |
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