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Characterisation of phosphate coacervates for potential biomedical applications

Pickup, D.M., Newport, Robert J., Barney, E.R., Kim, J.-Y., Valappil, S.P., Knowles, J.C. (2014) Characterisation of phosphate coacervates for potential biomedical applications. Journal of Biomaterials Applications, 28 (8). pp. 1226-1234. ISSN 0885-3282. (doi:10.1177/0885328213502586) (KAR id:46948)


In this study, amorphous (Na2O)x(CaO)0.50−x(P2O5)0.50·yH2O (where x = ∼0.15 and y = ∼3) samples were prepared by a coacervate method. Thermal analysis showed that two types of water molecules were present in the coacervate structures: one type loosely bound and the other part of the phosphate structure. Structural studies using Fourier transform infrared spectroscopy (FTIR) and X-ray total diffraction revealed the samples to have very similar structures to melt-quenched glasses of comparable composition. Furthermore, no significant structural differences were observed between samples prepared using calcium nitrate as the calcium source or those prepared from calcium chloride. A sample containing ∼1 mol% Ag2O was prepared to test the hypothesis that calcium phosphate coacervate materials could be used as delivery agents for antibacterial ions. This sample exhibited significant antibacterial activity against the bacterium Psuedomonas aeruginosa. FTIR data revealed the silver-doped sample to be structurally akin to the analogous silver-free sample.

Item Type: Article
DOI/Identification number: 10.1177/0885328213502586
Additional information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Biomater. Appl. [Field not mapped to EPrints] AD - School of Physical Sciences, Ingram Building, University of Kent, Canterbury, Kent CT2 7NH, United Kingdom [Field not mapped to EPrints] AD - Electrical Systems and Optics Research Division, Faculty of Engineering, University of Nottingham, Nottingham, United Kingdom [Field not mapped to EPrints] AD - WCU Research Centre of Nanobiomedical Science, Dankook University, Dongnam-gu, Cheonan-si, Chungnam, South Korea [Field not mapped to EPrints] AD - Department of Health Services Research, School of Dentistry, University of Liverpool, Research Wing, Liverpool, United Kingdom [Field not mapped to EPrints] AD - Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, London, United Kingdom [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled keywords: antibacterial, biomaterials, Coacervates, FTIR, phosphate glasses, X-ray total diffraction, Biological materials, Biomaterials, Calcium, Diffraction, Fourier transform infrared spectroscopy, Glass, Thermoanalysis, Anti-bacterial activity, antibacterial, Biomedical applications, Coacervates, FTIR, Melt-quenched glass, Phosphate glass, Structural differences, Medical applications, antiinfective agent, calcium, calcium chloride, calcium nitrate, calcium oxide, calcium phosphate, hydrogen, phosphate, silver, silver nitrate, silver oxide, sodium oxide, tripolyphosphate, unclassified drug, water, antibacterial activity, antibacterial assay, article, assay, biomedical engineering, chemical composition, chemical structure, coacervation, controlled study, growth inhibition, infrared spectroscopy, priority journal, Pseudomonas aeruginosa, thermal analysis, X ray diffraction
Subjects: Q Science > QC Physics > QC173.45 Condensed Matter
Q Science > QD Chemistry > QD478 Solid State Chemistry
Divisions: Divisions > Division of Natural Sciences > Physics and Astronomy
Depositing User: Giles Tarver
Date Deposited: 12 Feb 2015 15:00 UTC
Last Modified: 10 Dec 2022 04:08 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Pickup, D.M..

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Newport, Robert J..

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