The induction of angiogenesis by cerium oxide nanoparticles through the modulation of oxygen in intracellular environments

Das, S. and Singh, S. and Dowding, J.M. and Oommen, S. and Kumar, A. and Sayle, T.X.T. and Saraf, S. and Patra, C.R. and Vlahakis, N.E. and Sayle, D.C. and Self, W.T. and Seal, S. (2012) The induction of angiogenesis by cerium oxide nanoparticles through the modulation of oxygen in intracellular environments. Biomaterials, 33 (31). pp. 7746-7755. ISSN 01429612 (ISSN). (doi:https://doi.org/10.1016/j.biomaterials.2012.07.019) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Abstract

Angiogenesis is the formation of new blood vessels from existing blood vessels and is critical for many physiological and pathophysiological processes. In this study we have shown the unique property of cerium oxide nanoparticles (CNPs) to induce angiogenesis, observed using both in vitro and in vivo model systems. In particular, CNPs trigger angiogenesis by modulating the intracellular oxygen environment and stabilizing hypoxia inducing factor 1α endogenously. Furthermore, correlations between angiogenesis induction and CNPs physicochemical properties including: surface Ce3+/Ce4+ ratio, surface charge, size, and shape were also explored. High surface area and increased Ce3+/Ce4+ ratio make CNPs more catalytically active towards regulating intracellular oxygen, which in turn led to more robust induction of angiogenesis. Atomistic simulation was also used, in partnership with in vitro and in vivo experimentation, to reveal that the surface reactivity of CNPs and facile oxygen transport promotes pro-angiogenesis. © 2012 Elsevier Ltd.

Item Type: Article
Additional information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Biomaterials [Field not mapped to EPrints] C2 - 22858004 [Field not mapped to EPrints] AD - Department of Mechanical, Materials and Aerospace Engineering, Advanced Materials Processing Analysis Center, Nanoscience Technology Center, University of Central Florida, Orlando, FL, United States [Field not mapped to EPrints] AD - Burnett School of Biomedical Science, University of Central Florida, Orlando, FL, United States [Field not mapped to EPrints] AD - Div. Pulmonary and Critical Care, Mayo Clinic, Rochester, MN, United States [Field not mapped to EPrints] AD - Department of Engineering and Applied Science, Cranfield University, Defence Academy of the United Kingdom, Shrivenham SN6 8LA, United Kingdom [Field not mapped to EPrints] AD - Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, United States [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled keywords: Angiogenesis, Cerium oxide nanoparticle, Hypoxia inducing factor 1α, Intracellular oxygen concentration, Molecular dynamics, Surface reactivity, Angiogenesis, Atomistic simulations, Cerium oxide nanoparticle, High surface area, In-vitro, Oxygen concentrations, Oxygen transport, Pathophysiological, Physicochemical property, Surface reactivity, Blood vessels, Cerium compounds, Enzyme activity, Molecular dynamics, Nanoparticles, Oxides, Oxygen, cerium, cerium oxide, cerium oxide nanoparticle, hypoxia inducible factor 1alpha, nanoparticle, oxygen, unclassified drug, vasculotropin, angiogenesis, article, catalysis, controlled study, human, human cell, in vitro study, in vivo study, intracellular membrane, intracellular space, oxygen concentration, oxygen transport, particle size, physical chemistry, priority journal, simulation, surface charge, surface property, Animals, Cellular Microenvironment, Cerium, Chickens, Chorioallantoic Membrane, Endothelium, Vascular, Human Umbilical Vein Endothelial Cells, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Intracellular Space, Models, Molecular, Nanoparticles, Neovascularization, Physiologic, Oxidation-Reduction, Oxygen, Particle Size, Static Electricity, Surface Properties, Vascular Endothelial Growth Factor A
Subjects: Q Science
Divisions: Faculties > Sciences > School of Physical Sciences
Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Dean Sayle
Date Deposited: 27 Jan 2015 16:34 UTC
Last Modified: 27 Jan 2015 16:34 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/46775 (The current URI for this page, for reference purposes)
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