Benfield, Camilla, Smith, Sarah E., Wright, Edward, Wash, Rachael S., Ferrara, Francesca, Temperton, Nigel J., Kellam, Paul (2015) Bat and pig Interferon-Induced Transmembrane Protein 3 restrict cell entry by influenza virus and lyssaviruses. Journal of General Virology, 96 (5). ISSN 0022-1317. E-ISSN 1465-2099. (doi:10.1099/vir.0.000058) (KAR id:46718)
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Official URL http://dx.doi.org/10.1099/vir.0.000058 |
Abstract
Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor which
pathways. In humans and mice, IFITM3 limits influenza-induced morbidity and
function as antiviral restriction factors in mammalian species other than humans and
(Sus scrofa domesticus) were identified using rapid amplification of cDNA ends. Amino
bat orthologues. Ectopically-expressed pig and microbat IFITM3 co-localised with
trafficked from the plasma membrane into endosomes following live cell staining. Pig
and lyssavirus G proteins. Expression of pig or microbat IFITM3 in A549 cells reduced
IFITM3 in pig NPTr cells and primary microbat cells enhanced virus replication,
levels. In sum, we show that IFITMs function as potent broad-spectrum antiviral
viruses.
Item Type: | Article |
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DOI/Identification number: | 10.1099/vir.0.000058 |
Subjects: | Q Science > QR Microbiology > QR355 Virology |
Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
Depositing User: | Nigel Temperton |
Date Deposited: | 16 Jan 2015 12:53 UTC |
Last Modified: | 16 Feb 2021 13:22 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/46718 (The current URI for this page, for reference purposes) |
Temperton, Nigel J.: | ![]() |
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