Kelley, Stephen P., Mittleman, Guy (1999) Effects of hippocampal damage on reward threshold and response rate during self-stimulation of the ventral tegmental area in the rat. Behavioural brain research, 99 (2). pp. 133-141. ISSN 0166-4328. (doi:10.1016/S0166-4328(98)00097-7) (KAR id:46574)
PDF (Restricted due to publisher copyright policy)
Publisher pdf
Language: English |
|
Download this file (PDF/496kB) |
|
Request a format suitable for use with assistive technology e.g. a screenreader | |
Official URL: http://dx.doi.org/10.1016/S0166-4328(98)00097-7 |
Abstract
The main purpose of this study was to explore the role of the hippocampus in motivated behavior. Rats with bilateral excitotoxic lesions of the hippocampus and controls were trained to lever press for electrical stimulation of the ventral tegmental area. Rate intensity functions were generated from an ascending and descending series of current intensities. Lesion-induced changes in sensitivity to reward were distinguished from enhancements in motor output by calculating reward thresholds and maximal response rates from the rate-intensity functions. Rats with hippocampal damage showed lower reward thresholds and higher maximal response rates than controls. These results provide further evidence of hippocampal modulation of the nucleus accumbens, suggesting that lesions of this structure enhance sensitivity to reward and increase motor output.
Item Type: | Article |
---|---|
DOI/Identification number: | 10.1016/S0166-4328(98)00097-7 |
Uncontrolled keywords: | Hippocampus; Nucleus accumbens; Intra-cranial self-stimulation; Dopamine; Reward; Motivation |
Subjects: | R Medicine > RM Therapeutics. Pharmacology |
Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
Depositing User: | Stephen Kelley |
Date Deposited: | 07 Jan 2015 12:32 UTC |
Last Modified: | 16 Nov 2021 10:18 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/46574 (The current URI for this page, for reference purposes) |
- Link to SensusAccess
- Export to:
- RefWorks
- EPrints3 XML
- BibTeX
- CSV
- Depositors only (login required):