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Development of gene therapy vectors for combination radiotherapy of cancer

Scott, Simon D., Marples, B., Bourne, S., Walker, A., Joiner, M.C. (2001) Development of gene therapy vectors for combination radiotherapy of cancer. In: Cancer Gene Therapy. 8 (11). Springer-Nature (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:45889)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)

Abstract

The combination of gene therapy with radiotherapy offers exciting prospects

responsive vectors suitable for use with clinical radiation doses. The vectors

regulating expression of heterologous genes. The radio -induction of these

(GFP) reporter gene. Clinically relevant doses of ionising radiation ( 1 – 3

then used to drive the herpes simplex thymidine kinase/ ganciclovir

et al., 2000; Gene Therapy 7:511 – 517 ). In order to improve efficacy, we

arrangement. This data has enabled us to define some important criteria for

To provide long -term, constitutive gene expression and to markedly

scheme based on Cre/ Lox recombination was adopted. This resulted in a

et al., 2000; Gene Therapy 7:1121 – 1125 ). To further improve the overall

now been replaced with a single vector bearing all the active components.

model.

Item Type: Conference or workshop item (Poster)
Subjects: R Medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Simon Scott
Date Deposited: 03 Dec 2017 15:21 UTC
Last Modified: 29 May 2019 13:52 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/45889 (The current URI for this page, for reference purposes)
Scott, Simon D.: https://orcid.org/0000-0002-8290-0461
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