Highly Specific Targeting of Human Leukocytes Using Gold Nanoparticle-Based Biologically Active Conjugates

Gibbs, Bernhard F. and Yasinska, Inna M. and Calzolai, Luigi and Gilliland, Douglas and Sumbayev, Vadim V. (2014) Highly Specific Targeting of Human Leukocytes Using Gold Nanoparticle-Based Biologically Active Conjugates. Journal of Biomedical Nanotechnology, 10 (7). pp. 1259-1266. ISSN 1550-7033. E-ISSN 1550-7041. (doi:https://doi.org/10.1166/jbn.2014.1807) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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http://dx.doi.org/10.1166/jbn.2014.1807

Abstract

In this study we demonstrate for the first time a new approach for highly specific targeting of viable human leukocytes by functionalised gold nanoconjugates made on the basis of citrate-stabilised gold nanoparticles. This immobilisation involves highly specific recognition of the cells of interest by plasma membrane-associated receptor ligands or functional antibodies attached to gold nanoconjugates. Using this technology we managed to deliver pharmacological inhibitors into the target cells. Also we immobilized fully functional human leukocytes utilising both cell lines and rare primary human cells (basophils). This approach demonstrates possibilities of using nanoconjugates for diagnostics, drug delivery and immune therapy.

Item Type: Article
Uncontrolled keywords: Allergy; Basophils; Gold Nanoparticles; Leukaemia; Myeloid Leukaemia Cells
Subjects: Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Vadim Sumbayev
Date Deposited: 08 Dec 2014 12:47 UTC
Last Modified: 08 May 2018 08:48 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/45787 (The current URI for this page, for reference purposes)
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