Gibbs, Bernhard F., Yasinska, Inna M., Calzolai, Luigi, Gilliland, Douglas, Sumbayev, Vadim V. (2014) Highly Specific Targeting of Human Leukocytes Using Gold Nanoparticle-Based Biologically Active Conjugates. Journal of Biomedical Nanotechnology, 10 (7). pp. 1259-1266. ISSN 1550-7033. E-ISSN 1550-7041. (doi:10.1166/jbn.2014.1807) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:45787)
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Official URL: http://dx.doi.org/10.1166/jbn.2014.1807 |
Abstract
In this study we demonstrate for the first time a new approach for highly specific targeting of viable human leukocytes by functionalised gold nanoconjugates made on the basis of citrate-stabilised gold nanoparticles. This immobilisation involves highly specific recognition of the cells of interest by plasma membrane-associated receptor ligands or functional antibodies attached to gold nanoconjugates. Using this technology we managed to deliver pharmacological inhibitors into the target cells. Also we immobilized fully functional human leukocytes utilising both cell lines and rare primary human cells (basophils). This approach demonstrates possibilities of using nanoconjugates for diagnostics, drug delivery and immune therapy.
Item Type: | Article |
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DOI/Identification number: | 10.1166/jbn.2014.1807 |
Uncontrolled keywords: | Allergy; Basophils; Gold Nanoparticles; Leukaemia; Myeloid Leukaemia Cells |
Subjects: | Q Science > QP Physiology (Living systems) > QP517 Biochemistry |
Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
Depositing User: | Vadim Sumbayev |
Date Deposited: | 08 Dec 2014 12:47 UTC |
Last Modified: | 17 Aug 2022 10:58 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/45787 (The current URI for this page, for reference purposes) |
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