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H? receptors in mast cells and basophils: a new therapeutic target for allergy?

Gibbs, Bernhard F., Levi-Schaffer, Francesca (2012) H? receptors in mast cells and basophils: a new therapeutic target for allergy? Frontiers in Bioscience, 17 . pp. 430-437. ISSN 1093-9946. E-ISSN 1093-4715. (doi:10.2741/3936) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.2741/3936

Abstract

It has long been recognised that mast cells and basophils are prominent sources of preformed histamine in humans and that this biogenic amine serves as one of the most important inflammatory mediators. In allergic diseases, histamine has previously been shown to partially modulate symptoms such as airway obstruction, mucus secretion, reddening of the skin and itch, all of which were attributed to engagement of H1-receptors with the amine. However, more recently it has been shown that certain key biological functions of histamine, such as itch, are also crucially controlled by H4-receptor stimulation, resulting in a growing interest in combinational anti-H1 and -H4 therapeutic approaches. Moreover, research is beginning to shed light on a role of H4-receptors in mast cell precursor trafficking to various tissues commonly affected by allergic inflammation. Furthermore, H4-receptors are also expressed on mature basophils and other effector cells of allergic reactions, such as eosinophils. This presents exciting possibilities in terms of potentially modulating the pro-allergic function of these cells as well as preventing the effects of histamine on target organs and cells.

Item Type: Article
DOI/Identification number: 10.2741/3936
Projects: [UNSPECIFIED] Recent advances in histamine receptor H4R research
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Bernhard F. Gibbs
Date Deposited: 03 Dec 2014 11:35 UTC
Last Modified: 29 May 2019 13:49 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/45729 (The current URI for this page, for reference purposes)
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