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Expressions and inhibitory functions of CD300a receptors on purified human basophils.

Gibbs, Bernhard F., Sabato, Vito, Bridts, Chris H., Ebo, Didier E., Ben-Zimra, Micha, Levi-Schaffer, Francesca (2012) Expressions and inhibitory functions of CD300a receptors on purified human basophils. Experimental Dermatology, 21 (11). pp. 884-885. ISSN 0906-6705. (doi:10.1111/exd.12018) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
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http://onlinelibrary.wiley.com/doi/10.1111/exd.120...

Abstract

The inhibitory myeloid immunoglobulin receptor CD300a (IRp60) has been shown to downregulate mast cell and eosinophil activities, thereby serving as a potential target for inhibiting allergic effector cell input in allergy. Our aims were to study the expression and functional properties of this receptor in purified human basophils, cells that crucially contribute to Th2-type immunity and allergy. Basophils homogeneously expressed CD300a as well as the inhibitory receptor CD200R on their cell surface, and these expressions increased after anti-IgE stimulation. IgE-mediated basophil degranulation was also significantly inhibited by crosslinking of either CD200R or CD300a (by 90% and 50%, respectively). Inhibitory SHIP-1 phosphorylations were also induced by CD200R and CD300a, although they were not noticeably increased by IgE-dependent activation. We conclude that both CD200R and CD300a play a role in reducing IgE-mediated basophil function and may crucially govern the known differential activities of these cells in vivo.

Item Type: Article
DOI/Identification number: 10.1111/exd.12018
Subjects: Q Science > QR Microbiology > QR180 Immunology
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Bernhard F. Gibbs
Date Deposited: 03 Dec 2014 11:00 UTC
Last Modified: 29 May 2019 13:49 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/45723 (The current URI for this page, for reference purposes)
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