SHIP1 and the negative control of mast cell/basophil activation by supra-optimal antigen concentrations

Huber, Michael, Gibbs, Bernhard F. (2015) SHIP1 and the negative control of mast cell/basophil activation by supra-optimal antigen concentrations. Molecular Immunology, 63 (1). pp. 32-37. ISSN 0161-5890. (doi:10.1016/j.molimm.2014.02.017) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org/10.1016/j.molimm.2014.02.017

Abstract

IgE-mediated, antigen-triggered activation of mast cells and basophils often results in bell-shaped dose-response curves for the release of various pro-inflammatory mediators. The degree of suppression of mediator release observed following supra-optimal stimulation varies widely for different allergens as well as for different experimental agents that cause crosslinking of high-affinity IgE receptors (Fc?RI) on these cells. While the reasons for these differences have not yet been resolved it has become increasingly apparent that supra-optimal stimulation in many cases causes a shift in the balance of stimulatory and inhibitory signal transduction mechanisms arising from Fc?RI triggering. In particular, the lipid phosphatase SHIP1 has been shown to be centrally involved in explaining the bell-shaped phenomena in both mast cells and basophils in different species and appears to play a fundamental role in limiting the IgE responsiveness of these allergic effector cells. Elucidating the nature of this inhibitory signaling pathway may provide crucial knowledge in order to optimize desensitization strategies in the treatment of allergic diseases.

Item Type: Article
DOI/Identification number: 10.1016/j.molimm.2014.02.017
Uncontrolled keywords: Mast cell; Basophil; Lipid phosphatase; Signal transduction; Allergy
Subjects: Q Science > QP Physiology (Living systems) > QP506 Molecular biology
Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Q Science > QR Microbiology > QR180 Immunology
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Bernhard F. Gibbs
Date Deposited: 02 Dec 2014 16:58 UTC
Last Modified: 29 May 2019 13:49 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/45699 (The current URI for this page, for reference purposes)
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