Skip to main content

The impact of 8-aryl-and 8-heteroaryl-2'-deoxyguanosine derivatives on G-quadruplex formation

Gubala, V., Rivera-Sanchez, M.C., Hobley, G., Rivera, J.M. (2007) The impact of 8-aryl-and 8-heteroaryl-2'-deoxyguanosine derivatives on G-quadruplex formation. Nucleic acids symposium series, 51 (1). pp. 39-40. ISSN 1746-8272. (doi:10.1093/nass/nrm020)

PDF - Pre-print
Download (1MB) Preview
[img]
Preview
Official URL
https://doi.org/10.1093/nass/nrm020

Abstract

Guanine and G-rich oligonucleotides are known to self-assemble in the presence of a variety of cations to form higher ordered structures known as Gquadruplexes. We have synthesized a library of 8-aryl/heteroaryl-2'-deoxyguanosine derivatives (8ArGs) that are also able to self-assemble into quadruplex structures. We demonstrate that the properties of such quadruplexes can be modulated by the nature of the groups attached to the guanine base. These supramolecules are potentially useful in the development of self-assembled nanodevices.

Item Type: Article
DOI/Identification number: 10.1093/nass/nrm020
Additional information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Nucleic Acids Symp Ser (Oxf) [Field not mapped to EPrints] C2 - 18029575 [Field not mapped to EPrints] AD - Department of Chemistry, University of Puerto Rico, Río Piedras Campus, PO Box 23346, San Juan, Puerto Rico, 00931, USA. [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled keywords: deoxyguanosine, drug derivative, guanine quadruplex, nanomaterial, potassium, unclassified drug, article, chemistry, nuclear magnetic resonance, Deoxyguanosine, G-Quadruplexes, Nanostructures, Nuclear Magnetic Resonance, Biomolecular, Potassium
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Vladimir Gubala
Date Deposited: 14 Dec 2017 21:36 UTC
Last Modified: 29 May 2019 13:41 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/45248 (The current URI for this page, for reference purposes)
Gubala, V.: https://orcid.org/0000-0001-6301-3632
  • Depositors only (login required):

Downloads

Downloads per month over past year