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How do Antarctic notothenioid fishes cope with internal ice? A novel function for antifreeze glycoproteins

Evans, C.W., Gubala, V., Nooney, R., Williams, D.E., Brimble, M.A., Devries, A.L. (2010) How do Antarctic notothenioid fishes cope with internal ice? A novel function for antifreeze glycoproteins. Antarctic Science, 23 (1). pp. 57-64. ISSN 0954-1020. (doi:10.1017/S0954102010000635)

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Abstract

Antarctic fishes survive freezing through the secretion of antifreeze glycoproteins (AFGPs), which bind to ice crystals to inhibit their growth. This mode of action implies that ice crystals must be present internally for AFGPs to function. The entry and internal accumulation of ice is likely to be lethal, however, so how do fishes survive in its presence? We propose a novel function for the interaction between internal ice and AFGPs, namely the promotion of ice uptake by splenic phagocytes. We show here that i) external mucus of Antarctic notothenioids contains AFGPs and thus has a potential protective role against ice entry, ii) AFGPs are distributed widely through the extracellular space ensuring that they are likely to come into immediate contact with ice that penetrates their protective barriers, and iii) using AFGP-coated nanoparticles as a proxy for AFGP adsorbed onto ice, we suggest that internal ice crystals are removed from the circulation through phagocytosis, primarily in the spleen. We argue that intracellular sequestration in the spleen minimizes the risks associated with circulating ice and enables the fish to store the ice until it can be dealt with at a later date, possibly by melting during a seasonal warming event. Copyright © Antarctic Science Ltd 2011.

Item Type: Article
DOI/Identification number: 10.1017/S0954102010000635
Additional information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Antarct. Sci. [Field not mapped to EPrints] AD - School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand [Field not mapped to EPrints] AD - Biomedical Diagnostics Institute, Dublin City University, Glasnevin, Dublin 9, Ireland [Field not mapped to EPrints] AD - Department of Chemistry, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand [Field not mapped to EPrints] AD - MacDiarmid Institute for Advanced Materials and Nanotechnology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand [Field not mapped to EPrints] AD - Department of Animal Biology, University of Illinois at Urbana-Champaign, 524 Burrill Hall, 407 Sth. Goodwin, Urbana, IL 61801, United States [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled keywords: AFGP, nanoparticles, notothenioid, Pagothenia borchgrevinki, phagocytosis, adaptation, behavioral response, freezing, ice crystal, inhibition, perciform, protein, seasonal variation, secretion, survival, Pagothenia borchgrevinki, Pisces
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Vladimir Gubala
Date Deposited: 14 Dec 2017 20:24 UTC
Last Modified: 29 May 2019 13:41 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/45232 (The current URI for this page, for reference purposes)
Gubala, V.: https://orcid.org/0000-0001-6301-3632
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