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Potentiation of the resetting effects of light on circadian rhythms of hamsters using serotonin and neuropeptide Y receptor antagonists

Lall, Gurprit S., Harrington, M E (2006) Potentiation of the resetting effects of light on circadian rhythms of hamsters using serotonin and neuropeptide Y receptor antagonists. Neuroscience, 141 (3). pp. 1545-1552. ISSN 0306-4522. (doi:10.1016/j.neuroscience.2006.04.029) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Abstract

Circadian rhythms are entrained by light/dark cycles. In hamsters, the effects of light on circadian rhythms can be modulated by serotonergic input to the suprachiasmatic nucleus from the raphe nuclei and by neuropeptide Y containing afferents to the suprachiasmatic nucleus from the intergeniculate leaflet in the thalamus. In this study we measured effects of compounds acting on serotonergic 1A and neuropeptide Y Y5 receptors to determine if combined serotonergic-neuropeptide Y inhibition could synergistically potentiate effects of light on rhythms. We used mixed serotonergic agonist/antagonists BMY 7378 or NAN-190 as well as a neuropeptide Y Y5 antagonist CP-760,542. Both BMY 7378 and NAN-190 are thought to block serotonin release via acting as agonists at the 5-hydroxytryptamine 1A (5-HT1A) autoreceptors on cells in the raphe, and also block response of target cells by acting as antagonists at post-synaptic 5-HT1A receptors, for example, in the suprachiasmatic nuclei or the intergeniculate leaflet. Replicating prior work, we found that pretreatment with either drug alone increased the phase shift to light at circadian time 19. The combined effect of BMY 7378 and CP-760,542 given prior to light at circadian time 19 was to further potentiate the subsequent phase shift in wheel-running rhythms (the phase shift was 317% of controls; light alone: 1.35 h phase shift vs. BMY 7378, CP-760,542, and light: 4.27 h phase shift). Combined treatment with NAN-190 and CP-760,542 produced a light-induced phase shift 576% of controls (phase shift to light alone: 1.23 h vs. NAN-190, CP-760,542, and light: 7.1 h phase shift). These results suggest that the resetting effects of light on circadian rhythms can be greatly potentiated in hamsters by using pharmacological treatments that block both serotonergic and neuropeptide Y afferents to the suprachiasmatic nuclei.

Item Type: Article
DOI/Identification number: 10.1016/j.neuroscience.2006.04.029
Uncontrolled keywords: Animals Circadian Rhythm/*drug effects Cricetinae Drug Interactions Humans Light Mesocricetus Piperazines/pharmacology Receptor, Serotonin, 5-HT1A/*antagonists & inhibitors/physiology Receptors, Neuropeptide Y/*antagonists & inhibitors/physiology Serotonin Antagonists/*pharmacology Time Factors
Subjects: R Medicine
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Gurprit Lall
Date Deposited: 17 Nov 2014 15:34 UTC
Last Modified: 29 May 2019 13:33 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/44728 (The current URI for this page, for reference purposes)
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