Talin Dependent Mechanosensitivity of Cell Focal Adhesions

Yan, Jie and Yao, Mingxi and Goult, Benjamin T and Sheetz, Michael P. (2015) Talin Dependent Mechanosensitivity of Cell Focal Adhesions. Cellular and Molecular Bioengineering, 8 (1). pp. 151-159. ISSN 1865-5025. (doi:https://doi.org/10.1007/s12195-014-0364-5) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org/10.1007/s12195-014-0364-5

Abstract

A fundamental question in mechanobiology is how mechanical stimuli are sensed by mechanosensing proteins and converted into signals that direct cells to adapt to the external environment. A key function of cell adhesion to the extracellular matrix (ECM) is to transduce mechanical forces between cells and their extracellular environment. Talin, a cytoplasmic adapter essential for integrin-mediated adhesion to the ECM, links the actin cytoskeleton to integrin at the plasma membrane. Here, we review recent progress in the understanding of talin-dependent mechanosensing revealed by stretching single talin molecules. Rapid progress in single-molecule force manipulation technologies has made it possible to directly study the impact of mechanical force on talin’s conformations and its interactions with other signaling proteins. We also provide our views on how findings from such studies may bring new insights into understanding the principles of mechanobiology on a broader scale, and how such fundamental knowledge may be harnessed for mechanopharmacology.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Ben Goult
Date Deposited: 10 Nov 2014 09:18 UTC
Last Modified: 04 May 2018 11:26 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/44196 (The current URI for this page, for reference purposes)
Goult, Benjamin T: https://orcid.org/0000-0002-3438-2807
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