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The effect of 2 weeks vitamin C supplementation on immunoendocrine responses to 2.5 h cycling exercise in man.

Davison, Glen, Gleeson, Michael (2006) The effect of 2 weeks vitamin C supplementation on immunoendocrine responses to 2.5 h cycling exercise in man. European journal of applied physiology, 97 (4). pp. 454-61. ISSN 1439-6319. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:43977)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://link.springer.com/article/10.1007%2Fs00421-...

Abstract

An increased systemic concentration of stress hormones (of the hypothalamic-pituitary adrenal axis) and some cytokines may contribute to the depression of immune cell function typically observed after prolonged exercise. The aim of the present study was to determine the effect of 2 weeks of supplementation with vitamin C (VC) on cortisol, adrenocorticotrophic hormone, interleukin-6, oxidative stress and neutrophil responses to a single bout of endurance exercise. Nine healthy endurance-trained males exercised for 2.5 h at 60% VO2max after 2 weeks of placebo (PLA) or VC (1,000 mg day(-1)) supplementation. All participants completed both trials utilising a randomised crossover design with a minimum 14 day washout period between trials. There was a significant trial x time interaction effect for plasma cortisol concentration (P = 0.039) which tended to be lower in the VC trial but post hoc analysis found no specific between trial differences. There was a significantly lower post-exercise neutrophilia (P < 0.014) in the VC trial, compared with the PLA trial. There was no trial x time interaction for measures of neutrophil function (bacteria-stimulated elastase release, fMLP or PMA-stimulated oxidative burst). However, there was a trend for higher fMLP-stimulated neutrophil oxidative burst in the VC compared with PLA trial (trial x time interaction, P = 0.075). These results suggest that supplementation with VC for a period of up to 2 weeks provides little to no protection against the depression of neutrophil function which typically occurs after endurance exercise.

Item Type: Article
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > School of Sport and Exercise Sciences
Depositing User: Glen Davison
Date Deposited: 01 Nov 2014 23:15 UTC
Last Modified: 16 Feb 2021 12:56 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/43977 (The current URI for this page, for reference purposes)
Davison, Glen: https://orcid.org/0000-0003-4340-0074
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