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Antioxidant supplementation and immunoendocrine responses to prolonged exercise.

Davison, Glen, Gleeson, Michael, Phillips, Shaun (2007) Antioxidant supplementation and immunoendocrine responses to prolonged exercise. Medicine and science in sports and exercise, 39 (4). pp. 645-52. ISSN 0195-9131. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:43976)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
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Abstract

PURPOSE

Antioxidant supplementation may modulate systemic cortisol and interleukin-6 (IL-6) responses to prolonged exercise, but it is unclear whether such effects are also associated with a reduction in the magnitude of immunodepression. The purpose of the present study was to examine the effects of daily vitamin C (L-ascorbic acid, 1000 mg x d(-1)) and vitamin E (RRR-alpha-tocopherol, 400 IU x d(-1)) supplementation on immunoendocrine responses to prolonged exercise.

METHODS

Twenty healthy, recreationally active males cycled for 2.5 h at approximately 60% of maximal oxygen uptake after 4 wk of placebo (PLA, N=10) or antioxidant (AO, N=10) supplementation.

RESULTS

A significant group x time interaction was observed for plasma cortisol concentration (P=0.008), and the postexercise increase was greater (P<0.05) in the PLA compared with AO group (approximately 170% compared with an approximately 120% increase above baseline). Plasma IL-6 concentration was significantly increased after exercise to a similar extent in both groups. Plasma free F2-isoprostane concentration was significantly increased after exercise and was unaffected by AO supplementation, whereas plasma TBARS was unaffected by exercise in the PLA group but was lower after exercise in the AO group than in the PLA group. Circulating neutrophil count was significantly increased after exercise, and in vitro bacteria-stimulated elastase release per neutrophil was significantly decreased to a similar extent in both groups.

CONCLUSIONS

These results suggest that 4 wk of AO supplementation may blunt the cortisol response to a single 2.5-h bout of prolonged exercise independently of changes in oxidative stress or plasma IL-6 concentration, but it is not effective at modulating the exercise-induced neutrophilia or depression of neutrophil function.

Item Type: Article
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > School of Sport and Exercise Sciences
Depositing User: Glen Davison
Date Deposited: 01 Nov 2014 23:13 UTC
Last Modified: 16 Feb 2021 12:56 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/43976 (The current URI for this page, for reference purposes)
Davison, Glen: https://orcid.org/0000-0003-4340-0074
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