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Impact of Ethnicity, Gender, and Dehydration on the Urinary Excretion of Inhaled Salbutamol With Respect to Doping Control

Dickinson, John W., Hu, Jie, Chester, Neil, Loosemore, Mike, Whyte, Greg (2014) Impact of Ethnicity, Gender, and Dehydration on the Urinary Excretion of Inhaled Salbutamol With Respect to Doping Control. Clinical Journal of Sport Medicine, 24 (6). pp. 482-489. ISSN 1536-3724. (doi:10.1097/JSM.0000000000000072) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:43897)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1097/JSM.0000000000000072

Abstract

OBJECTIVE: To examine the impact of dehydration, ethnicity, and gender on urinary concentrations of salbutamol in relation to the threshold stipulated by the World Anti-Doping Agency (WADA). DESIGN: Repeated measures open-label. PARTICIPANTS: Eighteen male and 14 female athletes (9 white males, 9 white females, 2 Afro-Caribbean males, 2 Afro-Caribbean females, 6 Asian [Indian subcontinent] males, and 4 Asian females) were recruited. All participants were nonasthmatic. INTERVENTIONS: After inhalation of 800 μg or 1600 μg of salbutamol, athletes exercised in a hot controlled environment (35°C, 40% relative humidity) at a self-selected pace until a target weight loss (2% or 5%) was achieved. MAIN OUTCOME MEASURES: Urine concentration of free salbutamol. RESULTS: After inhalation of 1600 μg salbutamol, 20 participants presented with a urine salbutamol concentrations above the current WADA limit (1000 ng/mL) and decision limit (1200 ng/mL) resulting in an adverse analytical finding. There were no differences according to gender or ethnic origin. CONCLUSIONS: Dehydration equivalent to a body mass loss greater than 2% concomitant to the acute inhalation of 1600 μg of salbutamol may result in a urine concentration above the current WADA limit and decision limit leading to a positive test finding independent of gender or ethnic origin. CLINICAL RELEVANCE: Asthmatic athletes using salbutamol should receive clear dosing advise and education to minimize the risk of inhaling doses of salbutamol that may produce urine concentrations of salbutamol above 1200 ng/mL.

Item Type: Article
DOI/Identification number: 10.1097/JSM.0000000000000072
Subjects: R Medicine > RC Internal medicine > RC1200 Sports medicine
Divisions: Divisions > Division of Natural Sciences > School of Sport and Exercise Sciences
Depositing User: John Dickinson
Date Deposited: 27 Nov 2014 12:44 UTC
Last Modified: 16 Feb 2021 12:56 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/43897 (The current URI for this page, for reference purposes)
Dickinson, John W.: https://orcid.org/0000-0002-1824-7402
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