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Multiplex evaluation of influenza neutralizing antibodies with potential applicability to in-field serological studies

Molesti, Eleonora, Wright, Edward, Terregino, Calogero, Rahman, Rafat, Cattoli, Giovanni, Temperton, Nigel J. (2014) Multiplex evaluation of influenza neutralizing antibodies with potential applicability to in-field serological studies. In: International Meeting on Emerging Diseases and Surveillance (IMED 2014), 31 Oct - 03 Nov 2014, Vienna, Austria. (Unpublished) (doi:Poster 22.053) (KAR id:43721)

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Abstract

Purpose: The increased number of outbreaks of H5 and H7 LPAI and

The continuous rapid evolution of these subtypes and the emergence

Retroviral pseudotypes bearing influenza haemagglutinin (HA) and

for sensitive, readily standardized influenza serological assays.

that are directed against both influenza H5 and H7 HA. This assay

two antigenically distinct HAs in the same serum/plasma sample thus

acquired from valuable sera.

with a monovalent H5N2 vaccine, chickens vaccinated with a bivalent

were evaluated in the pseudotype assay (simple and multiplex format).

correlated strongly with data obtained by HI assay. We show that pseudotypes

and following multiple rounds of freeze-thaw.

utility for in-field serosurveillance and vaccine studies in resource-limited

regions worldwide.

Item Type: Conference or workshop item (Poster)
DOI/Identification number: Poster 22.053
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Nigel Temperton
Date Deposited: 27 Oct 2014 12:58 UTC
Last Modified: 16 Feb 2021 12:56 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/43721 (The current URI for this page, for reference purposes)
Temperton, Nigel J.: https://orcid.org/0000-0002-7978-3815
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