Discordant Correlation between Serological Assays Observed When Measuring Heterosubtypic Responses against Avian Influenza H5 and H7 Viruses in Unexposed Individuals

Purpose: The human population is constantly exposed to multiple

driven by intrinsic error-prone replication and immunological pressure.

of importance since they have been shown to correlate with protective

a critical role for influenza surveillance, vaccine development, and

outbreaks have demonstrated, there is an urgent need to be better prepared

against newly emerged viruses and to evaluate the extent of preexisting

Methods & Materials: SRH, HI, MN and pp-NT were used in a comparative

avian viruses in human sera.

population between 1992 and 2007 were found to be positive for antibodies

but most were negative when evaluated using haemagglutination inhibition

Conclusion: As a result of these discordant serological findings, the

based neutralisation (pp-NT) assays and the results obtained

against influenza A viruses.