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Methodological considerations for analyzing trabecular architecture: an example from the primate hand

Kivell, Tracy L., Skinner, Matthew M., Lazenby, Richard, Hublin, Jean-Jacques (2011) Methodological considerations for analyzing trabecular architecture: an example from the primate hand. Journal of Anatomy, 218 (2). pp. 209-225. ISSN 1469-7580. (doi:10.1111/j.1469-7580.2010.01314.x) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:43701)

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Micro-computed tomographic analyses of trabecular bone architecture have been used to clarify the link between positional behavior and skeletal anatomy in primates. However, there are methodological decisions associated with quantifying and comparing trabecular anatomy across taxa that vary greatly in body size and morphology that can affect characterizations of trabecular architecture, such as choice of the volume of interest (VOI) size and location. The potential effects of these decisions may be amplified in small, irregular-shaped bones of the hands and feet that have more complex external morphology and more heterogeneous trabecular structure compared to, for example, the spherical epiphysis of the femoral head. In this study we investigate the effects of changes in VOI size and location on standard trabecular parameters in two bones of the hand, the capitate and third metacarpal, in a diverse sample of nonhuman primates that vary greatly in morphology, body mass and positional behavior. Results demonstrate that changes in VOI location and, to a lesser extent, changes in VOI size had a dramatic affect on many trabecular parameters, especially trabecular connectivity and structure (rods vs. plates), degree of anisotropy, and the primary orientation of the trabeculae. Although previous research has shown that some trabecular parameters are susceptible to slight variations in methodology (e.g. VOI location, scan resolution), this study provides a quantification of these effects in hand bones of a diverse sample of primates. An a priori understanding of the inherent biases created by the choice of VOI size and particularly location is critical to robust trabecular analysis and functional interpretation, especially in small bones with complex arthroses.

Item Type: Article
DOI/Identification number: 10.1111/j.1469-7580.2010.01314.x
Uncontrolled keywords: body size;cancellous bone;carpal;homology;metacarpal;volume of interest
Subjects: Q Science
Q Science > QH Natural history
Q Science > QH Natural history > QH301 Biology
Q Science > QM Human anatomy
Divisions: Divisions > Division of Human and Social Sciences > School of Anthropology and Conservation
Depositing User: Tracy Kivell
Date Deposited: 29 Oct 2014 22:29 UTC
Last Modified: 16 Nov 2021 10:17 UTC
Resource URI: (The current URI for this page, for reference purposes)
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Skinner, Matthew M.:
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