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Scaling VOI size in 3D ?CT studies of trabecular bone: a test of the over-sampling hypothesis

Lazenby, Richard A, Skinner, Matthew M., Kivell, Tracy L., Hublin, Jean-Jacques (2011) Scaling VOI size in 3D ?CT studies of trabecular bone: a test of the over-sampling hypothesis. American Journal of Physical Anthropology, 144 (2). pp. 196-203. ISSN 1096-8644. (doi:10.1002/ajpa.21385) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Abstract

For comparative 3D microCT studies of trabecular bone, the use of a volume of interest (VOI) scaled to body size may avoid over-sampling the trabecular mass in smaller versus larger-bodied taxa and comparison of regions that are not functionally homologous (Fajardo and Müller: Am J Phys Anthropol 115 (2001) 327-336), though the influence on quantitative analyses using scaled versus nonscaled VOIs remains poorly characterized. We compare trabecular architectural properties reflecting mass, organization, and orientation from three volumes of interest (large, scaled, and small) obtained from the distal first metacarpal in a sample of Homo (n = 10) and Pan (n = 12). We test the null hypotheses that neither absolute VOI size, nor scaling of the VOI to metacarpal size as a proxy for body size, biases intraspecific analyses nor impacts the detection of interspecific differences. These hypotheses were only partially supported. While certain properties (e.g., bone volume fraction or trabecular thickness) were not affected by varying VOI size within taxa, others were significantly impacted (e.g., intersection surface, connectivity, and structure). In comparing large versus scaled VOIs, we found that the large VOI inflated the number and/or magnitude of significant differences between Homo and Pan. In summary, our results support the use of scaled VOIs in studies of trabecular architecture.

Item Type: Article
DOI/Identification number: 10.1002/ajpa.21385
Subjects: Q Science > QH Natural history
Q Science > QH Natural history > QH301 Biology
Q Science > QM Human anatomy
Divisions: Faculties > Social Sciences > School of Anthropology and Conservation
Faculties > Social Sciences > School of Anthropology and Conservation > Biological Anthropology
Depositing User: Tracy Kivell
Date Deposited: 29 Oct 2014 22:25 UTC
Last Modified: 07 Jun 2019 13:34 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/43700 (The current URI for this page, for reference purposes)
Skinner, Matthew M.: https://orcid.org/0000-0001-8321-3543
Kivell, Tracy L.: https://orcid.org/0000-0001-5087-0897
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