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Synonymous codons, ribosome speed, and eukaryotic gene expression regulation

Tarrant, Daniel, von der Haar, Tobias (2014) Synonymous codons, ribosome speed, and eukaryotic gene expression regulation. Cellular and Molecular Life Sciences, 71 (21). pp. 4195-4206. ISSN 1420-9071. (doi:10.1007/s00018-014-1684-2) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:43313)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1007/s00018-014-1684-2

Abstract

Quantitative control of gene expression occurs at multiple levels, including the level of translation. Within the overall process of translation, most identified regulatory processes impinge on the initiation phase. However, recent studies have revealed that the elongation phase can also regulate translation if elongation and initiation occur with specific, not mutually compatible rate parameters. Translation elongation then limits the overall amount of protein that can be made from an mRNA. Several recently discovered control mechanisms of biological pathways are based on such elongation control. Here, we review the molecular mechanisms that determine ribosome speed in eukaryotic organisms, and discuss under which conditions ribosome speed can become the controlling parameter of gene expression levels.

Item Type: Article
DOI/Identification number: 10.1007/s00018-014-1684-2
Uncontrolled keywords: Ribosome tRNA Codon usage Translational control Genetic code Evolution Gene regulation
Subjects: Q Science > QP Physiology (Living systems) > QP506 Molecular biology
Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Depositing User: Tobias von der Haar
Date Deposited: 13 Oct 2014 14:44 UTC
Last Modified: 29 May 2019 13:10 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/43313 (The current URI for this page, for reference purposes)
von der Haar, Tobias: https://orcid.org/0000-0002-6031-9254
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