Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

Selman, Colin, Tullet, Jennifer M.A., Wieser, Daniela, Irvine, Elaine, Lingard, Steven J, Choudhury, Agharul I, Claret, Marc, Al-Qassab, Hind, Carmignac, Danielle, Ramadani, Faruk, and others. (2009) Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (New York, N.Y.), 326 (5949). pp. 140-144. ISSN 0036-8075. E-ISSN 1095-9203. (doi:10.1126/science.1177221) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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http://dx.doi.org/10.1126/science.1177221

Abstract

Caloric restriction (CR) protects against aging and disease, but the mechanisms by which this affects mammalian life span are unclear. We show in mice that deletion of ribosomal S6 protein kinase 1 (S6K1), a component of the nutrient-responsive mTOR (mammalian target of rapamycin) signaling pathway, led to increased life span and resistance to age-related pathologies, such as bone, immune, and motor dysfunction and loss of insulin sensitivity. Deletion of S6K1 induced gene expression patterns similar to those seen in CR or with pharmacological activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), a conserved regulator of the metabolic response to CR. Our results demonstrate that S6K1 influences healthy mammalian life-span and suggest that therapeutic manipulation of S6K1 and AMPK might mimic CR and could provide broad protection against diseases of aging.

Item Type: Article
DOI/Identification number: 10.1126/science.1177221
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Jennifer Tullet
Date Deposited: 13 Oct 2014 08:31 UTC
Last Modified: 29 May 2019 13:09 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/43250 (The current URI for this page, for reference purposes)
Tullet, Jennifer M.A.: https://orcid.org/0000-0002-2037-526X
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