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Synthesis and Characterisation of Zirconium Complexes for Cell Tracking with Zr-89 by Positron Emission Tomography

Ferris, T.J., Charoenphun, P., Meszaros, L.K., Mullen, Gregory E. D., Blower, Philip J., Went, Michael J. (2014) Synthesis and Characterisation of Zirconium Complexes for Cell Tracking with Zr-89 by Positron Emission Tomography. Dalton Transactions, 43 (39). pp. 14851-14857. ISSN 1477-9226. E-ISSN 1477-9234. (doi:10.1039/c4dt01928h) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1039/c4dt01928h

Abstract

The increasing availability of the long half-life positron emitter Zr-89 (half life 78.4 h) suggests that it is a strong candidate for cell labelling and hence cell tracking using positron emission tomography. The aim was to produce a range of neutral ZrL4 lipophilic complexes for cell labelling which could be prepared under radiopharmaceutical conditions. This was achieved when the ligand was oxine, tropolone or ethyl maltol. The complexes can be prepared in high yield from zirconium(IV) precursors in hydrochloric or oxalic acid solution. The oxinate and tropolonate complexes were the most amenable to chromatographic characterisation, and HPLC and ITLC protocols have been established to monitor their radiochemical purity. The radiochemical synthesis and quality control of 89Zr(oxinate)4 is reported as well as preliminary cell labelling data for the oxinate, tropolonate and ethyl maltolate complexes which indicates that 89Zr(oxinate)4 is the most promising candidate for further evaluation.

Item Type: Article
DOI/Identification number: 10.1039/c4dt01928h
Subjects: Q Science > QD Chemistry
Divisions: Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Michael J Went
Date Deposited: 17 Sep 2014 07:40 UTC
Last Modified: 29 May 2019 13:05 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/42978 (The current URI for this page, for reference purposes)
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