Structural connectivity in a single case of progressive prosopagnosia: The role of the right inferior longitudinal fasciculus

Grossi, Dario and Soricelli, Andrea and Ponari, Marta and Salvatore, Elena and Quarantelli, Mario and Prinster, Anna and Trojano, Luigi (2014) Structural connectivity in a single case of progressive prosopagnosia: The role of the right inferior longitudinal fasciculus. Cortex, 56 . pp. 111-120. ISSN 0010-9452. (doi:https://doi.org/10.1016/j.cortex.2012.09.010) (Full text available)

Abstract

Progressive prosopagnosia (PP) is a clinical syndrome characterized by a progressive and selective inability to recognize and identify faces of familiar people. Here we report a patient (G.S.) with PP, mainly related to a prominent deficit in recognition of familiar faces, without a semantic (cross-modal) impairment. An in-depth evaluation showed that his deficit extended to other classes of objects, both living and non-living. A follow-up neuropsychological assessment did not reveal substantial changes after about 1 year. Structural MRI showed predominant right temporal lobe atrophy. Diffusion tensor imaging was performed to elucidate structural connectivity of the inferior longitudinal fasciculus (ILF) and the inferior fronto-occipital fasciculus (IFOF), the two major tracts that project through the core fusiform region to the anterior temporal and frontal cortices, respectively. Right ILF was markedly reduced in G.S., while left ILF and IFOFs were apparently preserved. These data are in favour of a crucial role of the neural circuit subserved by right ILF in the pathogenesis of PP.

Item Type: Article
Uncontrolled keywords: Diffusion tensor imaging; Inferior longitudinal fasciculus; Inferior fronto-occipital fasciculus; Progressive prosopagnosia
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Divisions: Faculties > Social Sciences > School of Psychology
Faculties > Social Sciences > School of Psychology > Cognitive Psychology
Depositing User: Marta Ponari
Date Deposited: 15 Sep 2014 12:35 UTC
Last Modified: 07 Dec 2015 15:25 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/42929 (The current URI for this page, for reference purposes)
Ponari, Marta: https://orcid.org/0000-0002-7658-8360
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