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Anticholinergics Exposure and the Risk of Cognitive Decline

Boustani, M., Fox, C., Richardson, K., Sawa, G.M., Smithard, D., Coulton, Simon, Katona, C., Maidment, I., Brayne, C. (2011) Anticholinergics Exposure and the Risk of Cognitive Decline. In: Journal of the American Geriatrics Society. 59 (S1). S68-S69. Blackwell Publishing (doi:10.1111/j.1532-5415.2011.03416.x) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:42680)

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Official URL
http://dx.doi.org/10.1111/j.1532-5415.2011.03416.x

Abstract

BACKGROUND: The role of modifiable risk factors for patients

with large population studies.

medication use and cognitive decline in the older population

in the Medical Research Council (MRC) Cognitive Function

SETTING: Community and institionalized participants.

and older.

as determined by the Anticholinergic Cognitive Burden

Examination (MMSE). The main outcome measure was decline on

RESULTS: At baseline, 47% of the population used a medication

definite anticholinergic properties. After adjusting for age, sex, educational

number of co-morbid health conditions and cognitive performance at

was associated with an additional reduction in MMSE score of 0.43

whereas the use of possible anticholinergics at baseline

CI -0.11, 0.11; p=0.98). Two year mortality was increased both for

1.30, 2.16; p<0.001) and for those taking possible anticholinergic medications

CONCLUSION: The benefits of prescribing definite anticholinergics

function and mortality among the older population.

Item Type: Conference or workshop item (Paper)
DOI/Identification number: 10.1111/j.1532-5415.2011.03416.x
Subjects: R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC952 Geriatrics
Divisions: Faculties > Social Sciences > School of Social Policy Sociology and Social Research > Centre for Health Services Studies
Depositing User: Simon Coulton
Date Deposited: 26 Aug 2014 12:55 UTC
Last Modified: 22 Jan 2020 04:06 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/42680 (The current URI for this page, for reference purposes)
Coulton, Simon: https://orcid.org/0000-0002-7704-3274
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