The globins of Campylobacter jejuni.

Tinajero-Trejo, Mariana and Shepherd, Mark (2013) The globins of Campylobacter jejuni. Advances in microbial physiology, 63 (1). pp. 97-145. ISSN 0065-2911. (doi:https://doi.org/10.1016/B978-0-12-407693-8.00004-2) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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http://dx.doi.org/10.1016/B978-0-12-407693-8.00004...

Abstract

Campylobacter jejuni is a zoonotic Gram-negative bacterial pathogen that is exposed to reactive nitrogen species, such as nitric oxide, from a variety of sources. To combat the toxic effects of this nitrosative stress, C. jejuni upregulates a small regulon under the control of the transcriptional activator NssR, which positively regulates the expression of a single-domain globin protein (Cgb) and a truncated globin protein (Ctb). Cgb has previously been shown to detoxify nitric oxide, but the role of Ctb remains contentious. As C. jejuni is amenable to genetic manipulation, and its globin proteins are easily expressed and purified, a combination of mutagenesis, complementation, transcriptomics, spectroscopic characterisation and structural analyses has been used to probe the regulation, function and structure of Cgb and Ctb. This ability to study Cgb and Ctb with such a multi-pronged approach is a valuable asset, especially since only a small fraction of known globin proteins have been functionally characterised.

Item Type: Article
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Mark Shepherd
Date Deposited: 07 Jul 2014 15:05 UTC
Last Modified: 28 Apr 2015 10:49 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/41703 (The current URI for this page, for reference purposes)
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