Streptomyces leeuwenhoekii sp. nov., the producer of chaxalactins and chaxamycins, forms a distinct branch in Streptomyces gene trees.

Busarakam, Kanungnid and Bull, Alan T. and Girard, Geneviève and Labeda, David P. and van Wezel, Gilles P. and Goodfellow, Michael (2014) Streptomyces leeuwenhoekii sp. nov., the producer of chaxalactins and chaxamycins, forms a distinct branch in Streptomyces gene trees. Antonie van Leeuwenhoek, 105 (5). pp. 849-861. ISSN 0003-6072. (doi:https://doi.org/10.1007/s10482-014-0139-y) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1007/s10482-014-0139-y

Abstract

A polyphasic study was carried out to establish the taxonomic status of an Atacama Desert isolate, Streptomyces strain C34T, which synthesises novel antibiotics, the chaxalactins and chaxamycins. The organism was shown to have chemotaxonomic, cultural and morphological properties consistent with its classification in the genus Streptomyces. Analysis of 16S rRNA gene sequences showed that strain C34T formed a distinct phyletic line in the Streptomyces gene tree that was very loosely associated with the type strains of several Streptomyces species. Multilocus sequence analysis based on five house-keeping gene alleles underpinned the separation of strain C34T from all of its nearest phylogenetic neighbours, apart from Streptomyces chiangmaiensis TA-1T and Streptomyces hyderabadensis OU-40T which are not currently in the MLSA database. Strain C34T was distinguished readily from the S. chiangmaiensis and S. hyderabadensis strains by using a combination of cultural and phenotypic data. Consequently, strain C34T is considered to represent a new species of the genus Streptomyces for which the name Streptomyces leeuwenhoekii sp. nov. is proposed. The type strain is C34T (= DSM 42122T = NRRL B-24963T). Analysis of the whole-genome sequence of S. leeuwenhoekii, with 6,780 predicted open reading frames and a total genome size of around 7.86 Mb, revealed a high potential for natural product biosynthesis.

Item Type: Article
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 20 May 2014 11:07 UTC
Last Modified: 15 Jul 2014 15:20 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/41092 (The current URI for this page, for reference purposes)
  • Depositors only (login required):