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In vitro and in silico investigations of drug delivery via zeolite BEA

Fatouros, Dimitrios, Douroumis, Dennis, Nikolakis, Vladimiros, Ntais, Spyridon, Moschovi, Anastasia Maria, Trivedi, Vivek, Khima, Bhavin, Roldo, Marta, Nazar, Hamde, Cox, Paul A. and others. (2011) In vitro and in silico investigations of drug delivery via zeolite BEA. Journal of Materials Chemistry, (21). pp. 7789-7794. ISSN 0959-9428. (doi:10.1039/c1jm10204d) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1039/c1jm10204d

Abstract

A combination of experiment and theory has been used to assess the potential use of the zeolite BEA as a drug delivery agent. Molecular dynamics (MD) has been used to examine the diffusion of two different drug molecules, salbutamol and theophylline, inside the zeolite BEA. MD shows that the two molecules display different diffusion behaviour, with the salbutamol molecule able to diffuse more freely than theophylline within the internal channel system of the zeolite. Several experimental techniques have been used to investigate the loading and release of the drug molecules from the BEA host. The results obtained support the observations from the modelling and suggest that modelling has an important role to play in screening zeolite–drug combinations prior to experimental investigation.

Item Type: Article
DOI/Identification number: 10.1039/c1jm10204d
Additional information: number of additional authors: 9;
Subjects: Q Science
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Stewart Brownrigg
Date Deposited: 07 Mar 2014 00:05 UTC
Last Modified: 20 Jun 2019 08:42 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/40430 (The current URI for this page, for reference purposes)
Trivedi, Vivek: https://orcid.org/0000-0001-9304-9214
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