Skip to main content

Inclusion of poorly soluble drugs in highly ordered mesoporous silica nanoparticles

Thomas, M. J. K, Slipper, I, Walunj, A, Jain, A, Favretto, M E, Kallinten, P, Douroumis, Dennis (2010) Inclusion of poorly soluble drugs in highly ordered mesoporous silica nanoparticles. International Journal of Pharmaceutics, 387 (1-2). pp. 272-277. ISSN 0378-5173. (doi:10.1016/j.ijpharm.2009.12.023) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1016/j.ijpharm.2009.12.023

Abstract

Silica nanoparticles (MSNs) with a highly ordered mesoporous structures (103 Å) with cubic View the MathML sourceIm3¯m have been synthesized using triblock copolymers with high poly(alkylene oxide) (EO) segments in acid media. The produced nanoparticles displayed large specific surface area (?765 cm2/g) with an average particles size of 120 nm. The loading efficiency was assessed by incorporating three major antiepileptic active substances via passive loading and it was found to varying from 17 to 25%. The state of the adsorbed active agents was further analyzed using differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD). Dissolution studies revealed rapid release profiles within the first 3 h. The viability of 3T3 endothelial cells was not affected in the presence of MSNs indicating negligible cytotoxicity.

Item Type: Article
DOI/Identification number: 10.1016/j.ijpharm.2009.12.023
Additional information: number of additional authors: 6;
Uncontrolled keywords: Mesoporous silica; SBA-16; Antiepileptic drugs; Loading; Cytotoxicity
Subjects: Q Science
R Medicine
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Stewart Brownrigg
Date Deposited: 07 Mar 2014 00:05 UTC
Last Modified: 29 May 2019 12:24 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/40428 (The current URI for this page, for reference purposes)
  • Depositors only (login required):