Convenient Solution-Phase Synthesis and Conformational Studies of Novel Linear and Cyclic a,ß-Alternating Peptoids

Hjelmgaard, Thomas, Faure, Sophie, Caumes, Cécile, De Santis, Emiliana, Edwards, Alison A., Taillefumier, Claude (2009) Convenient Solution-Phase Synthesis and Conformational Studies of Novel Linear and Cyclic a,ß-Alternating Peptoids. Organic Letters, 11 (18). pp. 4100-4103. ISSN 1523-7052. (doi:10.1021/ol9015767) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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http://dx.doi.org/10.1021/ol9015767

Abstract

The synthesis of a novel family of peptidomimetics composed of linear and cyclic ?,?-alternating peptoids is described. Oligomers consisting of up to six peptoid residues (n = 1?3) were synthesized on large scale with use of an efficient iterative solution-phase method and longer oligomers (n = 4, 5) were obtained by the coupling of appropriately protected shorter oligomers. Preliminary conformational studies of these hybrid peptoids are reported.

Item Type: Article
DOI/Identification number: 10.1021/ol9015767
Additional information: number of additional authors: 4;
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Stewart Brownrigg
Date Deposited: 07 Mar 2014 00:05 UTC
Last Modified: 29 May 2019 12:24 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/40411 (The current URI for this page, for reference purposes)
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