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The Effect of Engineered Mannitol-Lactose Mixture on Dry Powder Inhaler Performance

Kaialy, Waseem, Larhrib, Hassan, Martin, Gary P., Nokhodchi, Ali (2012) The Effect of Engineered Mannitol-Lactose Mixture on Dry Powder Inhaler Performance. Pharmaceutical Research, 29 (8). pp. 2139-2156. ISSN 1573-904X. (doi:10.1007/s11095-012-0743-3) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1007/s11095-012-0743-3

Abstract

Purpose To co-crystallise mannitol and lactose with a view to obtaining crystals with more favourable morphological features than either lactose or mannitol alone, suitable for use as carriers in formulations for dry powder inhalers (DPIs) using simultaneous engineering of lactose-mannitol mixtures. Methods Mannitol and lactose individually and the two sugars with three different ratios were crystallised/co-crystallised using anti-solvent precipitation technique. Obtained crystals were sieved to separate 63–90 ?m size fractions and then characterised by size, shape, density and in vitro aerosolisation performance. Solid state of crystallized samples was studied using FT-IR, XRPD and DSC. Results At unequal ratios of mannitol to lactose, the elongated shape dominated in the crystallisation process. However, lactose exerted an opposite effect to that of mannitol by reducing elongation ratio and increasing the crystals’ width and thickness. Crystallised ?-lactose showed different anomers compared to commercial lactose (?-lactose monohydrate). Crystallised ?-mannitol showed different polymorphic form compared to commercial mannitol (?-mannitol). Crystallised mannitol:lactose showed up to 5 transitions corresponding to ?-mannitol, ?-lactose monohydrate, ?-lactose, 5?-/3?-lactose and 4?-/1?-lactose. In vitro deposition assessments showed that crystallised carriers produced more efficient delivery of salbutamol sulphate compared to formulations containing commercial grade carriers. Conclusion The simultaneous crystallization of lactose-mannitol can be used as a new approach to improve the performance of DPI formulations.

Item Type: Article
DOI/Identification number: 10.1007/s11095-012-0743-3
Additional information: number of additional authors: 3;
Uncontrolled keywords: Fine carrier, in vitro aerosolisation, mannitol lactose ratio, salbutamol sulphate, shape, size, solid state, roughness.
Subjects: Q Science
R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Stewart Brownrigg
Date Deposited: 07 Mar 2014 00:05 UTC
Last Modified: 29 May 2019 12:24 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/40405 (The current URI for this page, for reference purposes)
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