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Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers

Srinivasan, Radhika, Gillett, Cheryl, Barnes, Diana M, Gullick, William J. (2000) Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers. Cancer Research, 60 (6). pp. 1483-1487. ISSN 0008-5472. (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Abstract

The prevalence and sites of expression of the c-erbB-4 receptor have been determined by immunocytochemical staining in a series of 178 human breast cancers. Most tumors displayed cytoplasmic staining of variable intensity. When compared with adjacent normal tissue, 32 cases (18%) showed lower than normal expression, and 13 (7%) showed greater than normal expression. Nuclear immunoreactivity, confirmed by two different antibodies, was present in 87 cancers (49%) but was found in normal adjacent breast epithelial cells in <5% of cases. There were no significant associations with cytoplasmic or membrane immunoreactivity, but cases showing nuclear expression in >25% of cells were associated with good histological grade, epidermal growth factor receptor expression, c-erbB-3 positivity, cripto, amphiregulin, and transforming growth factor-alpha overexpression.

Item Type: Article
Uncontrolled keywords: Biological Markers; Breast; Breast Neoplasms; Cell Membrane; Cell Nucleus; Cytoplasm; Epidermal Growth Factor; Female; Glycoproteins; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Membrane Glycoproteins; Neoplasm Invasiveness; Neoplasm Proteins; Nuclear Envelope; Receptor, Epidermal Growth Factor; erbB-3
Subjects: Q Science
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculties > Sciences > School of Biosciences > Biomedical Research Group
Depositing User: Bill Gullick
Date Deposited: 12 Jun 2008 11:53 UTC
Last Modified: 02 Jul 2019 09:39 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/3996 (The current URI for this page, for reference purposes)
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