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The Type 1 growth factor receptors and their ligands considered as a complex system

Gullick, William J. (2001) The Type 1 growth factor receptors and their ligands considered as a complex system. Endocrine Related Cancer, 8 (2). pp. 75-82. ISSN 1351-0088. (doi:10.1677/erc.0.0080075) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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The Type 1 family of growth factors and their receptors play an important role in normal development, wound healing and in diseases such as cancer. The products of the four receptor genes and the ten genes specifying ligands interact in a complex pattern. Such systems may develop emergent properties which cannot be predicted from a reductionist analysis of the interactions of individual components. New methods of determining these higher level properties are, however, being developed. These include microscopic analysis of live cells expressing fluorescently tagged ligands, receptors and second messengers which can provide positional information on components of the system. Computational simulations of the complex interactions are being developed which can help to predict the properties of the system.

Item Type: Article
DOI/Identification number: 10.1677/erc.0.0080075
Uncontrolled keywords: Animals Computer Simulation Growth Substances/genetics/metabolism/*physiology Humans Ligands Microscopy, Fluorescence Models, Biological Receptors, Growth Factor/genetics/metabolism/*physiology Second Messenger Systems/genetics/physiology
Subjects: Q Science
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculties > Sciences > School of Biosciences > Biomedical Research Group
Depositing User: Bill Gullick
Date Deposited: 12 Jun 2008 10:54 UTC
Last Modified: 28 May 2019 13:39 UTC
Resource URI: (The current URI for this page, for reference purposes)
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