Neuregulin 1-alpha expression in locally advanced breast cancer

Raj, E.H., Skinner, A., Mahji, U., Nirmala, K.N., Ravichandran, K., Shanta, V., Hurst, Helen C., Gullick, William J., Rajkumar, T. (2001) Neuregulin 1-alpha expression in locally advanced breast cancer. The Breast, 10 (1). pp. 41-45. ISSN 0960-9776. (doi:10.1054/brst.2000.0182) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Abstract

The human Neuregulin 1 (NRG1) gene encodes several alternatively spliced ligands that bind to both c-erbB-3 and c-erbB-4, members of the family of type 1 tyrosine kinase growth factor receptors. Antibodies raised to a synthetic peptide recognize selectively the alpha variant of NRG1. The NRG1-alpha isoforms' expression was studied in 115 locally advanced adenocarcinomas of the breast using immunohistochemistry. Absent or low levels of NRG1-alpha were found to be associated with poorer prognosis compared to tumours that had moderate to high levels of the protein.

Item Type: Article
DOI/Identification number: 10.1054/brst.2000.0182
Subjects: Q Science
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculties > Sciences > School of Biosciences > Biomedical Research Group
Depositing User: Bill Gullick
Date Deposited: 12 Jun 2008 10:27 UTC
Last Modified: 28 May 2019 13:39 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/3991 (The current URI for this page, for reference purposes)
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