Neuregulin 1-alpha expression in locally advanced breast cancer

Raj, E.H., Skinner, A., Mahji, U., Nirmala, K.N., Ravichandran, K., Shanta, V., Hurst, Helen C., Gullick, William J., Rajkumar, T. (2001) Neuregulin 1-alpha expression in locally advanced breast cancer. The Breast, 10 (1). pp. 41-45. ISSN 0960-9776. (doi:10.1054/brst.2000.0182) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:3991)

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Official URL: http://dx.doi.org/10.1054/brst.2000.0182

Abstract

The human Neuregulin 1 (NRG1) gene encodes several alternatively spliced ligands that bind to both c-erbB-3 and c-erbB-4, members of the family of type 1 tyrosine kinase growth factor receptors. Antibodies raised to a synthetic peptide recognize selectively the alpha variant of NRG1. The NRG1-alpha isoforms' expression was studied in 115 locally advanced adenocarcinomas of the breast using immunohistochemistry. Absent or low levels of NRG1-alpha were found to be associated with poorer prognosis compared to tumours that had moderate to high levels of the protein.

Item Type:	Article
DOI/Identification number:	10.1054/brst.2000.0182
Subjects:	Q Science R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	William Gullick
Date Deposited:	12 Jun 2008 10:27 UTC
Last Modified:	16 Nov 2021 09:42 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/3991 (The current URI for this page, for reference purposes)

University of Kent Author Information

Gullick, William J..

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