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A new model for ductal carcinoma in situ suggests strategies for treatment

Gullick, William J. (2002) A new model for ductal carcinoma in situ suggests strategies for treatment. Breast Cancer Research, 4 (5). pp. 176-178. ISSN 1465-5411. (doi:10.1186/bcr447) (KAR id:3986)


Human ductal carcinoma in situ (DCIS) of the breast is now diagnosed quite frequently, due largely to the introduction of mammographic screening. It has been shown in a cell culture system that activation of c-erbB-2, but not the epidermal growth factor receptor, results in a DCIS-like phenotype. Since overexpression of c-erbB-2 occurs in 60% of DCIS, this suggests that it could be a target for treatment in this disease.

Item Type: Article
DOI/Identification number: 10.1186/bcr447
Additional information: Free full-text article in PubMed Central and on Breast Cancer Research.
Uncontrolled keywords: ductal carcinoma in situ, growth factor receptor, tyrosine kinase inhibitor
Subjects: Q Science
R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: William Gullick
Date Deposited: 04 Sep 2008 14:11 UTC
Last Modified: 16 Nov 2021 09:42 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Gullick, William J..

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