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The role of the epidermal growth factor receptor in breast cancer

Chan, Samuel K. W., Hill, Mark E., Gullick, William J. (2006) The role of the epidermal growth factor receptor in breast cancer. Journal of Mammary Gland Biology and Neoplasia, 11 (1). pp. 3-11. ISSN 1083-3021. (doi:10.1007/s10911-006-9008-2) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:3971)

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Recent trials of drug therapy targeting the erbB receptor HER2 have met with success in breast cancer. The epidermal growth factor receptor or EGFR is a closely related receptor from this same family that is involved in cellular signal transduction and tumor cell growth and survival. Emerging evidence indicates that EGFR is implicated in the development of hormone-resistant breast cancer, and that its activity is intertwined with estrogen receptor. Here, the role of EGFR in breast cancer is reviewed, and data from selected clinical trials of signal transduction inhibition of this cellular target are summarized.

Item Type: Article
DOI/Identification number: 10.1007/s10911-006-9008-2
Uncontrolled keywords: Breast - ErbB - EGFR - Signal transduction - Hormone resistance - Gefitinib - Erlotinib
Subjects: Q Science
R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Depositing User: William Gullick
Date Deposited: 30 Aug 2008 20:43 UTC
Last Modified: 16 Feb 2021 12:16 UTC
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