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Radiotherapy and Cellular Signalling

Lewanski, Conrad R., Gullick, William J. (2001) Radiotherapy and Cellular Signalling. Lancet Oncology, 2 (6). pp. 366-370. ISSN 1470-2045. (doi:10.1016/S1470-2045(00)00391-0) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:3952)

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Developments in cellular and molecular biology in the past decade have increased our understanding of the processes by which cells respond to ionising radiation. Cells use complex protein signalling systems that recognise radiation damage to DNA and plasma membrane lipids. When damage is found, it leads to the activation of various intracellular pathways that modulate the activity of genes controlling ceflular responses such as apoptosis, cell-cycle arrest, or repair. Numerous molecular targets may be activated or inhibited in an attempt to upregulatre or downregulate the radiation response. In this review, we discuss some of the new compounds and techniques for manipulating the cell's response to radiation.

Item Type: Article
DOI/Identification number: 10.1016/S1470-2045(00)00391-0
Additional information: Review Article
Subjects: Q Science
R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: William Gullick
Date Deposited: 25 Sep 2009 14:29 UTC
Last Modified: 16 Nov 2021 09:42 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Gullick, William J..

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