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Investigation into Cu-64-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents

McQuade, Paul, Martin, Kath E., Castle, Thomas C., Went, Michael J., Blower, Philip J., Welch, Michael J., Lewis, Jason S. (2005) Investigation into Cu-64-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents. Nuclear Medicine and Biology, 32 (2). pp. 147-156. ISSN 0883-2897. (doi:10.1016/j.nucmedbio.2004.10.004) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:3764)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1016/j.nucmedbio.2004.10.004

Abstract

Background: Cu-diacetyl-bis(N-4-methylthiosemicarbazone)[Cu-ATSM], although excellent for oncology applications, may not be suitable for delineating cardiovascular or neurological hypoxia. For this reason, new Cu hypoxia positron emission tomography (PET) imaging agents are being examined to search for a higher selectivity for hypoxic or ischemic tissue at higher oxygen concentrations found in these tissues. Two approaches are to increase alkylation or to replace the sulfur atoms with selenium, resulting in the formation of selenosemicarbazones.

Conclusion: Of the compounds synthesized, only Cu-64-ASSM and Cu-64-ATSE could be examined in vitro and in vivo. Although the stability of bis(selenosemicarbazone) complexes increased upon addition of methyl groups to the diimine backbone, the fully alkylated species, Cu-64-ASSM, demonstrated no hypoxia selectivity. However, the additional alkylation present in Cu-ATSE modifies the hypoxia selectivity and in vivo properties when compared with Cu-ATSM.

Item Type: Article
DOI/Identification number: 10.1016/j.nucmedbio.2004.10.004
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Divisions > Division of Natural Sciences > School of Physical Sciences
Depositing User: Michael Went
Date Deposited: 30 Aug 2008 20:51 UTC
Last Modified: 16 Feb 2021 12:15 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/3764 (The current URI for this page, for reference purposes)
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