Analysis of neuron-specific Enolase and S100B as biomarkers of cognitive decline following surgery in older people

Jones, Emma L. and Gauge, Nathan and Nilsen, Odd Bjarte and Lowery, David and Wesnes, Keith and Katsaiti, Eirini and Arden, James and Amoako, Derek and Prophet, Nicholas and Purushothaman, Balaji and Green, David and Ballard, Clive G. (2012) Analysis of neuron-specific Enolase and S100B as biomarkers of cognitive decline following surgery in older people. Dementia and Geriatric Cognitive Disorders, 34 (5/6). pp. 307-311. ISSN 1420-8008. (doi:https://doi.org/10.1159/000345538) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org/10.1159/000345538

Abstract

Background/Aims: Post-operative cognitive decline is frequent in older individuals following major surgery; however, biomarkers of this decline are less clearly defined. Methods: Sixty-eight participants over the age of 60 provided blood samples at baseline and 24 h post-surgery. Cognitive decline was measured at baseline and 52 weeks post-surgery using the Cambridge Assessment for Mental Disorder in the Elderly, section B (CAMCOG) score. Plasma levels of neuron-specific enolase (NSE) and S100B were measured by ELISA. Results: Baseline NSE and the change in NSE levels between baseline and 24 h were correlated with the change in CAMCOG score between baseline and 52 weeks. Conclusion: NSE concentrations may be a useful predictor of individuals at risk of more severe long-term cognitive decline.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC952 Geriatrics
R Medicine > RD Surgery
Divisions: Faculties > Social Sciences > School of Social Policy Sociology and Social Research > Centre for Health Services Studies
Depositing User: Tony Rees
Date Deposited: 20 Nov 2013 09:26 UTC
Last Modified: 26 Jun 2014 08:40 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/36614 (The current URI for this page, for reference purposes)
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